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IPR008504 is a ER membrane protein complex subunit 6.
<p>This entry represents ER membrane protein complex subunit 6 (Emc6). Emc6 is a component of the ER membrane protein complex (EMC), which is composed of Emc1, Emc2, Emc3, Emc4, Emc5 and Emc6 in budding yeast [[cite:PUB00061987]]. The EMC complex is required for efficient folding of proteins in the ER and enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins [[cite:PUB00061987], [cite:PUB00067575], [cite:PUB00096679], [cite:PUB00096681], [cite:PUB00096682]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | ||
| Cellular component | ER membrane protein complex | A transmembrane protein complex located in the ER that is involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ER membrane protein complex subunit 6-like isoform X3 [Cicer arietinum] gi|502080345|ref|XP_004486534.1| | 9 | ||
| – | ER membrane protein complex subunit 6; TAIR: AT5G49540.1 Rab5-interacting family protein; Swiss-Prot: sp|Q1ZXH4|EMC6_DICDI ER membrane protein complex subunit 6; TrEMBL-Plants: tr|C6SYQ2|C6SYQ2_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0261100 | 8 | ||
| – | ER membrane protein complex subunit 6; TAIR: AT5G49540.1 Rab5-interacting family protein; Swiss-Prot: sp|Q3ZCG8|EMC6_BOVIN ER membrane protein complex subunit 6; TrEMBL-Plants: tr|A0A151T672|A0A151T672_CAJCA Transmembrane protein 93; Found in the gene: LotjaGi6g1v0261100 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 33.33 |