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IPR008778 is a Pirin, C-terminal domain.
<p>Eukaryotic pirins are highly conserved nuclear proteins that may function as transcriptional regulators with a role in apoptosis [[cite:PUB00057391], [cite:PUB00020125]]. Prokaryotic homologues have also been identified. Both bacterial and human pirins have been shown to possess quercetinase activity [[cite:PUB00046681]], although this is not universally true for all family members - YhaK ([swissprot:P42624]), for example, displays no such enzymatic activity [[cite:PUB00049698]].</p> <p>Pirin is composed of two structurally similar domains arranged face to face. Although the two domains are similar, the C-terminal domain of pirin differs from the N-terminal domain as it does not contain a metal binding site and its sequence does not contain the conserved metal-coordinating residues [[cite:PUB00020127]].</p> <p>Pirin is considered a member of the cupin superfamily on the basis of primary sequence and structural similarity. The presence of a metal binding site in the N-terminal β-barrel of pirin, may be significant in its interaction with Bcl-3 and nuclear factor I (NFI) and role in regulating NF-kappaB transcription factor activity [[cite:PUB00020127]].</p> <p>This entry represents the Pirin C-terminal domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pirin-like protein-like [Glycine max] gi|356552737|ref|XP_003544719.1| | 12 | ||
| – | PREDICTED: pirin-like protein-like [Glycine max] gi|356552737|ref|XP_003544719.1| | 12 | ||
| – | Pirin-like protein; TAIR: AT1G50590.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|Q9LPS9|PRNL1_ARATH Pirin-like protein At1g50590; TrEMBL-Plants: tr|A0A0B2SAS7|A0A0B2SAS7_GLYSO Pirin-like protein; Found in the gene: LotjaGi1g1v0021700 | 12 | ||
| – | Pirin-like protein; TAIR: AT1G50590.1 RmlC-like cupins superfamily protein; Swiss-Prot: sp|Q9LPS9|PRNL1_ARATH Pirin-like protein At1g50590; TrEMBL-Plants: tr|A0A0B2SAS7|A0A0B2SAS7_GLYSO Pirin-like protein; Found in the gene: LotjaGi1g1v0021700 | 12 | ||
| – | Pirin-like protein; TAIR: AT2G43120.2 RmlC-like cupins superfamily protein; Swiss-Prot: sp|Q9SEE4|PIRL_SOLLC Pirin-like protein; TrEMBL-Plants: tr|I1N5F6|I1N5F6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0554500 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51182 | SUPERFAMILY | 1 | 20.00 |