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IPR008947 is a Phospholipase C/P1 nuclease domain superfamily.
<p>The enzymes belonging to this superfamily are involved in phosphate ester hydrolysis and contain a triad of closely spaced zinc ions at their active centres. Both families of enzymes hydrolyse phosphodiesters. Substrates for phospholipase C are phosphatidylinositol and phosphatidylcholine, while P1 nuclease is an endonuclease hydrolysing single stranded ribo-and deoxyribonucleotides. P1 nuclease also has activity as a phosphomonoesterase against 3'-terminal phosphates of nucleotides. The Zn ions in both enzymes form almost identical trinuclear sites [[cite:PUB00010629]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Hydrolase activity, acting on ester bonds | Catalysis of the hydrolysis of any ester bond. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Nuclease S1 [Medicago truncatula] gi|357488641|ref|XP_003614608.1| | 14 | ||
– | Endonuclease [Medicago truncatula] gi|357488645|ref|XP_003614610.1| | 7 | ||
– | Nuclease S1 [Medicago truncatula] gi|357488641|ref|XP_003614608.1| | 8 | ||
– | PREDICTED: endonuclease 4-like isoform X1 [Cicer arietinum] gi|502142497|ref|XP_004504986.1| | 15 | ||
– | PREDICTED: nuclease S1-like [Glycine max] gi|356575560|ref|XP_003555908.1| | 14 | ||
– | Endonuclease [Medicago truncatula] gi|357446373|ref|XP_003593464.1| | 14 | ||
– | Endonuclease, partial [Lotus japonicus] gi|50657594|gb|AAT79581.1| | 8 | ||
– | Nuclease S1; TAIR: AT1G68290.1 endonuclease 2; Swiss-Prot: sp|Q9C9G4|ENDO2_ARATH Endonuclease 2; TrEMBL-Plants: tr|I1J6M1|I1J6M1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0276000 | 15 | ||
– | Nuclease S1; TAIR: AT1G68290.1 endonuclease 2; Swiss-Prot: sp|Q9C9G4|ENDO2_ARATH Endonuclease 2; TrEMBL-Plants: tr|A0A1J7HPH3|A0A1J7HPH3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0276000 | 8 | ||
– | Nuclease S1; TAIR: AT1G68290.1 endonuclease 2; Swiss-Prot: sp|Q9C9G4|ENDO2_ARATH Endonuclease 2; TrEMBL-Plants: tr|A0A1J7HPH3|A0A1J7HPH3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0276000 | 12 | ||
– | Nuclease S1; TAIR: AT4G21585.1 endonuclease 4; Swiss-Prot: sp|F4JJL0|ENDO4_ARATH Endonuclease 4; TrEMBL-Plants: tr|I3SW41|I3SW41_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0050700 | 14 | ||
– | Nuclease S1; TAIR: AT1G68290.1 endonuclease 2; Swiss-Prot: sp|Q9C9G4|ENDO2_ARATH Endonuclease 2; TrEMBL-Plants: tr|I1NFK4|I1NFK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0339100 | 14 | ||
– | Nuclease S1; TAIR: AT1G11190.1 bifunctional nuclease i; Swiss-Prot: sp|Q9SXA6|ENDO1_ARATH Endonuclease 1; TrEMBL-Plants: tr|I3SHH3|I3SHH3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0337400 | 14 | ||
– | Nuclease S1; TAIR: AT1G11190.1 bifunctional nuclease i; Swiss-Prot: sp|Q9SXA6|ENDO1_ARATH Endonuclease 1; TrEMBL-Plants: tr|I3SHH3|I3SHH3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0337400 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd11010 | CDD | 1 | 7.14 |