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IPR010073 is a Phosphoribosylformylglycinamidine synthase PurL.
<p>This entry represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is known as large PurL and is found mostly in eukaryotes and proteobacteria. In Bacillus subtilis PurL (FGAM synthase II), PurQ (FGAM synthase I) and PurS, of unknown function, perform the equivalent function [[cite:PUB00014926]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phosphoribosylformylglycinamidine synthase activity | Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. | ||
| Biological process | 'de novo' IMP biosynthetic process | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phosphoribosylformylglycinamidine synthase; TAIR: AT1G74260.1 purine biosynthesis 4; Swiss-Prot: sp|Q9M8D3|PUR4_ARATH Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072U5E4|A0A072U5E4_MEDTR Phosphoribosylformylglycinamidine synthase; Found in the gene: LotjaGi2g1v0405000 | 27 | ||
| – | Phosphoribosylformylglycinamidine synthase; TAIR: AT1G74260.1 purine biosynthesis 4; Swiss-Prot: sp|Q9M8D3|PUR4_ARATH Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072TUU6|A0A072TUU6_MEDTR Phosphoribosylformylglycinamidine synthase; Found in the gene: LotjaGi6g1v0063600 | 31 | ||
| – | Phosphoribosylformylglycinamidine synthase; TAIR: AT1G74260.1 purine biosynthesis 4; Swiss-Prot: sp|Q9M8D3|PUR4_ARATH Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072TUU6|A0A072TUU6_MEDTR Phosphoribosylformylglycinamidine synthase; Found in the gene: LotjaGi6g1v0063600 | 31 | ||
| – | Phosphoribosylformylglycinamidine synthase; TAIR: AT1G74260.1 purine biosynthesis 4; Swiss-Prot: sp|Q9M8D3|PUR4_ARATH Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072U5E4|A0A072U5E4_MEDTR Phosphoribosylformylglycinamidine synthase; Found in the gene: LotjaGi6g1v0063600 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02204 | CDD | 1 | 25.00 |