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IPR010358 is a BRCA1-A complex subunit BRE.
<p>Brain and reproductive organ-expressed (BRE, also known as BRCC45) is a component of the BRCA1-A complex, a complex that specifically recognises 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) [[cite:PUB00081453]]. It acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer [[cite:PUB00081743], [cite:PUB00060076]]. It is also part of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates [[cite:PUB00054087], [cite:PUB00084981], [cite:PUB00084982], [cite:PUB00081742]]. Within the BRISC complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity [[cite:PUB00081743]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | BRCA1-A complex | A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. | ||
| Cellular component | BRISC complex | A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: BRCA1-A complex subunit BRE-like isoform X2 [Cicer arietinum] gi|502080026|ref|XP_004486438.1| | 4 | ||
| – | BRCA1-A complex subunit BRE; TAIR: AT5G42470.1 BRCA1-A complex subunit BRE-like protein; Swiss-Prot: sp|Q568D5|BRE_DANRE BRCA1-A complex subunit BRE; TrEMBL-Plants: tr|I3SXL6|I3SXL6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0275300 | 3 | ||
| – | BRCA1-A complex subunit BRE; TAIR: AT5G42470.1 BRCA1-A complex subunit BRE-like protein; Swiss-Prot: sp|Q568D5|BRE_DANRE BRCA1-A complex subunit BRE; TrEMBL-Plants: tr|I3SXL6|I3SXL6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0275300 | 3 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR15189 | PANTHER | 1 | 33.33 |