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IPR011082 is a Exosome-associated factor Rrp47/DNA strand repair C1D.
<p>The CD1 family of proteins includes exosome-associated cofactor Rrp47, and DNA double-strand repair protein C1D. Both of these proteins are implicated in DNA double-strand repair and in nuclear exosome activity.</p> <p>Rrp47 functions in nuclear RNA processing. Rrp47 is associated with nuclear exosomes, and with the nuclear exosome-specific 3'-5' exonuclease Rrp6.Rrp47 appears to be a substrate-specific nuclear cofactor that is required for the 3' processing of pre-rRNAs, snoRNAs and snRNAs (specifically U4 and U5) [[cite:PUB00014272]]. However, Rrp47 is not required for cytoplasmic exosome mRNA degradation. It also appears to have a role in DNA strand repair.</p> <p>C1D is an inducible nuclear matrix proteins that interacts with and activates the DNA-dependent protein kinase essential for DNA double-strand repair and V(D)J recombination [[cite:PUB00035574]]. C1D can interact with condensin, which is required for DNA repair and replication checkpoint control [[cite:PUB00035576]]. C1D also binds to nuclear exosomes and might regulate their functional activities, as it has RNA-binding activity [[cite:PUB00035575]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nuclear nucleic acid-binding protein C1D [Medicago truncatula] gi|357466007|ref|XP_003603288.1| | 6 | ||
| – | Sas10/Utp3/C1D family [Theobroma cacao] gi|508782070|gb|EOY29326.1| | 4 | ||
| – | Sas10/Utp3/C1D family [Theobroma cacao] gi|508782070|gb|EOY29326.1| | 4 | ||
| – | Nuclear nucleic acid-binding protein C1D; TAIR: AT5G25080.1 Sas10/Utp3/C1D family; Swiss-Prot: sp|Q3KPR1|C1D_XENLA Nuclear nucleic acid-binding protein C1D; TrEMBL-Plants: tr|I1K8L9|I1K8L9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0376600 | 6 | ||
| – | Nuclear nucleic acid-binding protein C1D; TAIR: AT5G25080.1 Sas10/Utp3/C1D family; Swiss-Prot: sp|Q5ZHS3|C1D_CHICK Nuclear nucleic acid-binding protein C1D; TrEMBL-Plants: tr|C6T2F3|C6T2F3_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0052600 | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |