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IPR011304

Source: InterPro

Description

IPR011304 is a L-lactate dehydrogenase.

<p>This entry represents the NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes. This enzyme functions as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified [[cite:PUB00013812]] which can discriminate between the two activities.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004459
Molecular function L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
Subterm of
GO:0005737
Cellular component Cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj2g3v2002130.1
– PREDICTED: L-lactate dehydrogenase A-like [Glycine max] gi|356497151|ref|XP_003517426.1|
Domains
21
Lj4g3v1273790.1
– PREDICTED: L-lactate dehydrogenase A-like [Glycine max] gi|356497151|ref|XP_003517426.1|
Domains
21
LotjaGi2g1v0424500.1
– L-lactate dehydrogenase; TAIR: AT4G17260.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|P22988|LDHA_HORVU L-lactate dehydrogenase A; TrEMBL-Plants: tr|I1J9W9|I1J9W9_SOYBN L-lactate dehydrogenase; Found in the gene: LotjaGi2g1v0424500
Domains
21
LotjaGi4g1v0205000.1
– L-lactate dehydrogenase; TAIR: AT4G17260.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|P22988|LDHA_HORVU L-lactate dehydrogenase A; TrEMBL-Plants: tr|G7JIY5|G7JIY5_MEDTR L-lactate dehydrogenase; Found in the gene: LotjaGi4g1v0205000
Domains
22
LotjaGi4g1v0205000.2
– L-lactate dehydrogenase; TAIR: AT4G17260.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|P22988|LDHA_HORVU L-lactate dehydrogenase A; TrEMBL-Plants: tr|G7JIY5|G7JIY5_MEDTR L-lactate dehydrogenase; Found in the gene: LotjaGi4g1v0205000
Domains
22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd05293 CDD 1 20.00