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IPR001236 is a Lactate/malate dehydrogenase, N-terminal.
<p>L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis [[cite:PUB00025866]]. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate [[cite:PUB00027386]]. The enzyme participates in the citric acid cycle.</p> <p>This entry represents the N-terminal, and is thought to be a Rossmann NAD-binding fold.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: malate dehydrogenase, chloroplastic-like [Glycine max] gi|356512147|ref|XP_003524782.1| | 18 | ||
| – | Malate dehydrogenase [Medicago truncatula] gi|357476083|ref|XP_003608327.1| | 19 | ||
| – | PREDICTED: malate dehydrogenase [NADP] gi|356535509|ref|XP_003536287.1| | 8 | ||
| – | Malate dehydrogenase, glyoxysomal [Medicago truncatula] gi|357482443|ref|XP_003611508.1| | 19 | ||
| – | PREDICTED: L-lactate dehydrogenase A-like [Glycine max] gi|356497151|ref|XP_003517426.1| | 21 | ||
| – | Malate dehydrogenase [Glycine max] gi|5929964|gb|AAD56659.1| | 18 | ||
| – | PREDICTED: malate dehydrogenase, mitochondrial-like [Glycine max] gi|356517066|ref|XP_003527211.1| | 18 | ||
| – | PREDICTED: malate dehydrogenase, cytoplasmic-like [Cicer arietinum] gi|502155536|ref|XP_004510111.1| | 27 | ||
| – | PREDICTED: L-lactate dehydrogenase A-like [Glycine max] gi|356497151|ref|XP_003517426.1| | 21 | ||
| – | Nodule-enhanced malate dehydrogenase [Pisum sativum] gi|3377762|gb|AAC28106.1| | 19 | ||
| – | Cytosolic malate dehydrogenase [Lupinus angustifolius] gi|328908589|gb|AEB60994.1| | 21 | ||
| – | PREDICTED: malate dehydrogenase [NADP] gi|356535509|ref|XP_003536287.1| | 8 | ||
| – | PREDICTED: malate dehydrogenase, cytoplasmic-like [Cicer arietinum] gi|502122643|ref|XP_004497846.1| | 21 | ||
| – | PREDICTED: L-lactate dehydrogenase A-like [Cicer arietinum] gi|502181547|ref|XP_004516830.1| | 9 | ||
| – | L-lactate dehydrogenase; TAIR: AT4G17260.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|P29038|LDH_MAIZE L-lactate dehydrogenase; TrEMBL-Plants: tr|G7JIY5|G7JIY5_MEDTR L-lactate dehydrogenase; Found in the gene: LotjaGi1g1v0559500_LC | 8 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 17 | ||
| – | L-lactate dehydrogenase; TAIR: AT4G17260.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|P22988|LDHA_HORVU L-lactate dehydrogenase A; TrEMBL-Plants: tr|I1J9W9|I1J9W9_SOYBN L-lactate dehydrogenase; Found in the gene: LotjaGi2g1v0424500 | 21 | ||
| – | Malate dehydrogenase; TAIR: AT1G53240.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q9ZP06|MDHM1_ARATH Malate dehydrogenase 1, mitochondrial; TrEMBL-Plants: tr|I3T024|I3T024_LOTJA Malate dehydrogenase; Found in the gene: LotjaGi3g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G56720.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q08062|MDHC_MAIZE Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|G7LBJ9|G7LBJ9_MEDTR Cytoplasmic-like malate dehydrogenase; Found in the gene: LotjaGi3g1v0554700 | 27 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q08062|MDHC_MAIZE Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|A0A0L9VUQ6|A0A0L9VUQ6_PHAAN Malate dehydrogenase; Found in the gene: LotjaGi3g1v0554700 | 16 | ||
| – | Malate dehydrogenase; TAIR: AT5G56720.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q08062|MDHC_MAIZE Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|G7LBJ9|G7LBJ9_MEDTR Cytoplasmic-like malate dehydrogenase; Found in the gene: LotjaGi3g1v0554700 | 24 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | L-lactate dehydrogenase; TAIR: AT4G17260.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|P22988|LDHA_HORVU L-lactate dehydrogenase A; TrEMBL-Plants: tr|G7JIY5|G7JIY5_MEDTR L-lactate dehydrogenase; Found in the gene: LotjaGi4g1v0205000 | 22 | ||
| – | L-lactate dehydrogenase; TAIR: AT4G17260.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|P22988|LDHA_HORVU L-lactate dehydrogenase A; TrEMBL-Plants: tr|G7JIY5|G7JIY5_MEDTR L-lactate dehydrogenase; Found in the gene: LotjaGi4g1v0205000 | 22 | ||
| – | Malate dehydrogenase; TAIR: AT3G47520.1 malate dehydrogenase; Swiss-Prot: sp|Q9SN86|MDHP_ARATH Malate dehydrogenase, chloroplastic; TrEMBL-Plants: tr|I3SFA8|I3SFA8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0249500 | 17 | ||
| – | Malate dehydrogenase; TAIR: AT3G47520.1 malate dehydrogenase; Swiss-Prot: sp|Q9SN86|MDHP_ARATH Malate dehydrogenase, chloroplastic; TrEMBL-Plants: tr|I3SFA8|I3SFA8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0249500 | 17 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|F5B9G0|F5B9G0_LUPAN Malate dehydrogenase; Found in the gene: LotjaGi5g1v0190900 | 22 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|U5G3W6|U5G3W6_POPTR Malate dehydrogenase; Found in the gene: LotjaGi5g1v0190900 | 21 | ||
| – | Malate dehydrogenase; TAIR: AT5G58330.2 lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48902|MDHP_MEDSA Malate dehydrogenase [NADP], chloroplastic; TrEMBL-Plants: tr|A0A0R0HW29|A0A0R0HW29_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0254100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G43330.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|O48905|MDHC_MEDSA Malate dehydrogenase, cytoplasmic; TrEMBL-Plants: tr|I3SCX2|I3SCX2_LOTJA Malate dehydrogenase; Found in the gene: LotjaGi6g1v0005300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01336 | CDD | 1 | 2.70 |