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IPR011388 is a Sphingolipid delta4-desaturase.
<p>This group represents sphingolipid delta-4 desaturase (DEGS), an integral membrane protein required for sphingosine biosynthesis. It converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) [[cite:PUB00014620]]. Delta4-desaturated sphingolipids provide an early signal that triggers the entry into both meiotic and spermatid differentiation pathways during Drosophila spermatogenesis [[cite:PUB00014620]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | ||
| Biological process | Sphingolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). | ||
| Molecular function | Sphingolipid delta-4 desaturase activity | Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: sphingolipid delta(4)-desaturase DES1-like [Cicer arietinum] gi|502077808|ref|XP_004485750.1| | 13 | ||
| – | Sphingolipid delta-4 desaturase; TAIR: AT4G04930.1 fatty acid desaturase family protein; Swiss-Prot: sp|Q6H5U3|DES1L_ORYSJ Sphingolipid delta(4)-desaturase DES1-like; TrEMBL-Plants: tr|I3SQJ0|I3SQJ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0333400 | 14 | ||
| – | Sphingolipid delta-4 desaturase; TAIR: AT4G04930.1 fatty acid desaturase family protein; Swiss-Prot: sp|Q6H5U3|DES1L_ORYSJ Sphingolipid delta(4)-desaturase DES1-like; TrEMBL-Plants: tr|I3SQJ0|I3SQJ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0333400 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03508 | CDD | 1 | 33.33 |