Description

IPR011765 is a Peptidase M16, N-terminal.

<p>This entry represents an N-terminal domain found in metallopeptidases and non-peptidase homologues belonging to MEROPS peptidase family M16 (clan ME), subfamilies M16A, M16B and M16C. Members of this group of proteins include:</p> <ul><li>Insulinase, insulin-degrading enzyme ([ec:3.4.24.56])</li> <li>Mitochondrial processing peptidase alpha subunit, (Alpha-MPP, [ec:3.4.24.64])</li> <li>Pitrilysin, Protease III precursor ([ec:3.4.24.55])</li> <li>Nardilysin ([ec:3.4.24.61])</li> <li>Ubiquinol-cytochrome C reductase complex core protein I,mitochondrial precursor ([ec:1.10.2.2])</li> <li>Coenzyme PQQ synthesis protein F ([ec:3.4.99])</li></ul> <p>These proteins do not share many regions of sequence similarity; the most noticeable is in the N-terminal section. This region includes a conserved histidine followed, two residues later by a glutamate and another histidine. In pitrilysin, it has been shown [[cite:PUB00004194]] that this H-x-x-E-H motif is involved in enzymatic activity; the two histidines bind zinc and the glutamate is necessary for catalytic activity. The proteins classified as non-peptidase homologues either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 26

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: