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IPR011249

Source: InterPro

Description

IPR011249 is a Metalloenzyme, LuxS/M16 peptidase-like.

<p>This entry represents domains with a two-layer α/β structure found in metalloenzymes such as LuxS (S-ribosylhomocysteinase; [ec:4.4.1.21]) and metallopeptidases belonging to MEROPS peptidase family M16. These domains share the same active site motif of HxxEH located in the first core helix, but differ in one of the metal-binding residues. LuxS, the AI-2 (autoinducer-2) producing enzyme for quorum sensing in bacteria, is a homodimeric iron-dependent metalloenzyme containing two identical tetrahedral metal-binding sites similar to those found in peptidases and amidases, although it contains an extra N-terminal strand [[cite:PUB00032627], [cite:PUB00025993]]. Some M16 family metallopeptidases, such as mitochondrial processing peptidase (MPP), share the same common fold elaborated with many extra additional structures [[cite:PUB00010202]]. These peptidases usually contain a duplication of this domain, although only the N-terminal domain binds the catalytic metal.</p> <p>Domains found in metallopeptidases and non-peptidase homologues belonging to MEROPS peptidase family M16 (clan ME), subfamilies M16A, M16B and M16C; include:</p> <ul> <li>Insulinase, insulin-degrading enzyme ([ec:3.4.24.56])</li> <li>Mitochondrial processing peptidase alpha subunit, (Alpha-MPP, [ec:3.4.24.64])</li> <li>Pitrlysin, Protease III precursor ([ec:3.4.24.55])</li> <li>Nardilysin, ([ec:3.4.24.61])</li> <li>Ubiquinol-cytochrome C reductase complex core protein I,mitochondrial precursor ([ec:1.10.2.2])</li> <li>Coenzyme PQQ synthesis protein F ([ec:3.4.99])</li></ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003824
Molecular function Catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
Subterm of
GO:0046872
Molecular function Metal ion binding Interacting selectively and non-covalently with any metal ion.
Subterm of

Associated Lotus transcripts 34

Transcript Name Description Predicted domains Domain count
Lj0g3v0009849.1
– PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1|
Domains
15
Lj0g3v0009859.1
– PREDICTED: insulin-degrading enzyme-like [Glycine max] gi|356569463|ref|XP_003552920.1|
Domains
8
Lj0g3v0249059.1
– PREDICTED: probable mitochondrial-processing peptidase subunit beta-like [Cicer arietinum] gi|502103363|ref|XP_004492264.1|
Domains
13
Lj0g3v0249059.2
– PREDICTED: probable mitochondrial-processing peptidase subunit beta-like [Cicer arietinum] gi|502103363|ref|XP_004492264.1|
Domains
11
Lj0g3v0331639.1
– PREDICTED: zinc-metallopeptidase, peroxisomal-like isoform X2 [Cicer arietinum] gi|502108825|ref|XP_004493496.1|
Domains
14
Lj1g3v0013380.1
– PREDICTED: presequence protease 1, chloroplastic/mitochondrial-like [Cicer arietinum] gi|502158789|ref|XP_004511282.1|
Domains
14
Lj1g3v0130120.1
– Metalloendopeptidase [Medicago truncatula] gi|357481067|ref|XP_003610819.1|
Domains
10
Lj3g3v2318320.1
– PREDICTED: mitochondrial-processing peptidase subunit alpha-like [Cicer arietinum] gi|502156126|ref|XP_004510321.1|
Domains
12
Lj4g3v1983560.1
– PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1|
Domains
15
Lj4g3v3019490.1
– PREDICTED: probable zinc protease pqqL-like [Glycine max] gi|356523679|ref|XP_003530463.1|
Domains
12
Lj4g3v3031660.1
– PREDICTED: mitochondrial-processing peptidase subunit alpha-like [Cicer arietinum] gi|502138725|ref|XP_004503508.1|
Domains
13
Lj6g3v0315180.1
– PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1|
Domains
10
Lj6g3v0315180.2
– PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1|
Domains
13
LotjaGi1g1v0592600.1
– Mitochondrial processing peptidase; TAIR: AT3G02090.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|Q42290|MPPB_ARATH Probable mitochondrial-processing peptidase subunit beta, mitochondrial; TrEMBL-Plants: tr|A0A072TYG3|A0A072TYG3_MEDTR Processing peptidase; Found in the gene: LotjaGi1g1v0592600
Domains
19
LotjaGi1g1v0673200_LC.1
– Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|A0A068VEI9|A0A068VEI9_COFCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0673200_LC
Domains
8
LotjaGi1g1v0673200_LC.2
– Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|A0A068VEI9|A0A068VEI9_COFCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0673200_LC
Domains
8
LotjaGi1g1v0718900.1
– Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|K7KEW2|K7KEW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0718900
Domains
13
LotjaGi1g1v0718900.2
– Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|K7KEW2|K7KEW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0718900
Domains
13
LotjaGi1g1v0718900.3
– Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|K7KEW2|K7KEW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0718900
Domains
13
LotjaGi2g1v0450800.4
– Peptidase M16 family protein; TAIR: AT5G42390.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|Q40983|SPP_PEA Stromal processing peptidase, chloroplastic; TrEMBL-Plants: tr|I1LFY1|I1LFY1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0450800
Domains
9
LotjaGi2g1v0462000.1
– Presequence protease, mitochondrial; TAIR: AT3G19170.1 presequence protease 1; Swiss-Prot: sp|Q9LJL3|PREP1_ARATH Presequence protease 1, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UDY2|A0A072UDY2_MEDTR Presequence protease; Found in the gene: LotjaGi2g1v0462000
Domains
12
LotjaGi2g1v0462000.2
– Presequence protease, mitochondrial; TAIR: AT3G19170.1 presequence protease 1; Swiss-Prot: sp|Q9LJL3|PREP1_ARATH Presequence protease 1, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UDY2|A0A072UDY2_MEDTR Presequence protease; Found in the gene: LotjaGi2g1v0462000
Domains
8
LotjaGi2g1v0462000.3
– Mitochondrial presequence protease; TAIR: AT3G19170.1 presequence protease 1; Swiss-Prot: sp|Q9LJL3|PREP1_ARATH Presequence protease 1, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UDY2|A0A072UDY2_MEDTR Presequence protease; Found in the gene: LotjaGi2g1v0462000
Domains
10
LotjaGi2g1v0462000.4
– Mitochondrial presequence protease; TAIR: AT3G19170.1 presequence protease 1; Swiss-Prot: sp|Q9LJL3|PREP1_ARATH Presequence protease 1, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UDY2|A0A072UDY2_MEDTR Presequence protease; Found in the gene: LotjaGi2g1v0462000
Domains
10
LotjaGi2g1v0462000.5
– Presequence protease, mitochondrial; TAIR: AT3G19170.1 presequence protease 1; Swiss-Prot: sp|Q9LJL3|PREP1_ARATH Presequence protease 1, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UDY2|A0A072UDY2_MEDTR Presequence protease; Found in the gene: LotjaGi2g1v0462000
Domains
12
LotjaGi2g1v0462000.6
– Presequence protease, mitochondrial; TAIR: AT3G19170.1 presequence protease 1; Swiss-Prot: sp|Q9LJL3|PREP1_ARATH Presequence protease 1, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UDY2|A0A072UDY2_MEDTR Presequence protease; Found in the gene: LotjaGi2g1v0462000
Domains
12
LotjaGi2g1v0462000.7
– Mitochondrial presequence protease; TAIR: AT1G49630.1 presequence protease 2; Swiss-Prot: sp|Q8VY06|PREP2_ARATH Presequence protease 2, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A0R4J2L6|A0A0R4J2L6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0462000
Domains
10
LotjaGi3g1v0372500.1
– Mitochondrial-processing peptidase subunit alpha; TAIR: AT1G51980.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|P29677|MPPA_SOLTU Mitochondrial-processing peptidase subunit alpha; TrEMBL-Plants: tr|I1KGH6|I1KGH6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0372500
Domains
12
LotjaGi4g1v0442000.1
– Mitochondrial-processing peptidase subunit beta, mitochondrial, putative; TAIR: AT5G56730.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|Q9FJT9|PQQL_ARATH Zinc protease PQQL-like; TrEMBL-Plants: tr|A0A0B2Q5Y0|A0A0B2Q5Y0_GLYSO Putative zinc protease pqqL; Found in the gene: LotjaGi4g1v0442000
Domains
15
LotjaGi4g1v0442000.2
– Peptidase M16 family protein; TAIR: AT5G56730.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|Q9FJT9|PQQL_ARATH Zinc protease PQQL-like; TrEMBL-Plants: tr|A0A0B2NRZ3|A0A0B2NRZ3_GLYSO Putative zinc protease pqqL; Found in the gene: LotjaGi4g1v0442000
Domains
7
LotjaGi4g1v0442000.3
– Mitochondrial-processing peptidase subunit beta, mitochondrial, putative; TAIR: AT5G56730.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|Q9FJT9|PQQL_ARATH Zinc protease PQQL-like; TrEMBL-Plants: tr|A0A0B2NRZ3|A0A0B2NRZ3_GLYSO Putative zinc protease pqqL; Found in the gene: LotjaGi4g1v0442000
Domains
11
LotjaGi4g1v0442000.4
– Peptidase M16 family protein; TAIR: AT5G56730.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|Q9FJT9|PQQL_ARATH Zinc protease PQQL-like; TrEMBL-Plants: tr|A0A1J7GWK0|A0A1J7GWK0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0442000
Domains
11
LotjaGi4g1v0443400.1
– Mitochondrial-processing peptidase subunit alpha; TAIR: AT1G51980.1 Insulinase (Peptidase family M16) protein; Swiss-Prot: sp|P29677|MPPA_SOLTU Mitochondrial-processing peptidase subunit alpha; TrEMBL-Plants: tr|G7L7C9|G7L7C9_MEDTR Processing peptidase; Found in the gene: LotjaGi4g1v0443400
Domains
13
LotjaGi6g1v0042300.1
– Insulin-degrading enzyme; TAIR: AT1G06900.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|F4HNU6|NRDC_ARATH Nardilysin-like; TrEMBL-Plants: tr|A0A072UY22|A0A072UY22_MEDTR Insulin-degrading enzyme; Found in the gene: LotjaGi6g1v0042300
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 2.94