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IPR032632 is a Peptidase M16, middle/third domain.
<p>This is the third domain of some M16 peptidases, such as insulin-degrading-enzyme in eukaryotes or protease 3 from bacteria [[cite:PUB00076549]]. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolise several bioactive peptides, including insulin and the amyloid-β-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four [[cite:PUB00076546]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1| | 15 | ||
| – | PREDICTED: zinc-metallopeptidase, peroxisomal-like isoform X2 [Cicer arietinum] gi|502108825|ref|XP_004493496.1| | 14 | ||
| – | PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1| | 15 | ||
| – | PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1| | 10 | ||
| – | PREDICTED: nardilysin-like isoform X1 [Cicer arietinum] gi|502129594|ref|XP_004500358.1| | 13 | ||
| – | Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|K7KEW2|K7KEW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0718900 | 13 | ||
| – | Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|K7KEW2|K7KEW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0718900 | 13 | ||
| – | Insulin-degrading enzyme; TAIR: AT2G41790.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|O22941|IDE1_ARATH Insulin-degrading enzyme-like 1, peroxisomal; TrEMBL-Plants: tr|K7KEW2|K7KEW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0718900 | 13 | ||
| – | Insulin-degrading enzyme; TAIR: AT1G06900.1 Insulinase (Peptidase family M16) family protein; Swiss-Prot: sp|F4HNU6|NRDC_ARATH Nardilysin-like; TrEMBL-Plants: tr|A0A072UY22|A0A072UY22_MEDTR Insulin-degrading enzyme; Found in the gene: LotjaGi6g1v0042300 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |