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IPR011876

Source: InterPro

Description

IPR011876 is a Isopentenyl-diphosphate delta-isomerase, type 1.

<p>This entry represents type 1 of two non-homologous families of the enzyme isopentenyl-diphosphate delta-isomerase (IPP isomerase; [ec:5.3.3.2]). IPP isomerase is a member of the Nudix hydrolase superfamily, and is a key enzyme in the isoprenoid biosynthetic pathway. It catalyses the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate. Dimethylallyl phosphate is the initial substrate for the biosynthesis of carotenoids and other long chain isoprenoids [[cite:PUB00004916]]. IPP is an essential building block for many compounds, including enzyme cofactors, sterols, and prenyl groups. This enzyme interconverts isopentenyl diphosphate and dimethylallyl diphosphate. The enzyme requires one Mn2+ or Mg2+ ion in its active site to fold into an active conformation and also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as a metal binding and catalytic site. The metal binding site is present within the active site and plays structural and catalytical roles. IPP isomerase is well represented in several bacteria, archaebacteria and eukaryotes, including fungi, mammals and plants. Despite sequence variations (mainly at the N terminus), the core structure is highly conserved [[cite:PUB00080771]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004452
Molecular function Isopentenyl-diphosphate delta-isomerase activity Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.
Subterm of
GO:0008299
Biological process Isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v2823900.1
– Isopentenyl pyrophosphate isomerase [Pueraria montana var]. lobata] gi|35186998|gb|AAQ84167.1|
Domains
12
LotjaGi1g1v0485600.1
– Isopentenyl-diphosphate delta-isomerase; TAIR: AT3G02780.1 isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2; Swiss-Prot: sp|O48965|IDI2_CAMAC Isopentenyl-diphosphate Delta-isomerase II; TrEMBL-Plants: tr|A0A0S3RSE2|A0A0S3RSE2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485600
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd02885 CDD 1 50.00