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IPR000086

Source: InterPro

Description

IPR000086 is a NUDIX hydrolase domain.

<p>The Nudix superfamily is widespread among eukaryotes, bacteria, archaea and viruses and consists mainly of pyrophosphohydrolases that act upon substrates of general structure NUcleoside DIphosphate linked to another moiety, X (NDP-X) to yield NMP plus P-X. Such substrates include (d)NTPs (both canonical and oxidised derivatives), nucleotide sugars and alcohols, dinucleoside polyphosphates (NpnN), dinucleotide coenzymes and capped RNAs. However, phosphohydrolase activity, including activity towards NDPs themselves, and non-nucleotide substrates such as diphosphoinositol polyphosphates (DIPs), 5-phosphoribosyl 1-pyrophosphate (PRPP), thiamine pyrophosphate (TPP) and dihydroneopterin triphosphate (DHNTP) have also been described. Some superfamily members, such as Escherichia coli mutT, have the ability to degrade potentially mutagenic, oxidised nucleotides while others control the levels of metabolic intermediates and signalling compounds. In procaryotes and simple eucaryotes, the number of Nudix genes varies from 0 to over 30, reflecting the metabolic complexity and adaptability of the organism. Nudix hydrolases are typically small proteins, larger ones having additional domains with interactive or other catalytic functions [[cite:PUB00034750]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016787
Molecular function Hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
Subterm of

Associated Lotus transcripts 71

Transcript Name Description Predicted domains Domain count
Lj0g3v0079109.1
– PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356553271|ref|XP_003544981.1|
Domains
11
Lj0g3v0105609.1
– Nudix hydrolase [Medicago truncatula] gi|357476761|ref|XP_003608666.1|
Domains
12
Lj0g3v0105609.2
– Nudix hydrolase [Medicago truncatula] gi|357476761|ref|XP_003608666.1|
Domains
13
Lj0g3v0162539.1
– Nudix hydrolase [Medicago truncatula] gi|357500493|ref|XP_003620535.1|
Domains
17
Lj0g3v0201549.1
– PREDICTED: nudix hydrolase 16, mitochondrial-like [Glycine max] gi|356556803|ref|XP_003546710.1|
Domains
11
Lj0g3v0296919.1
– PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356502376|ref|XP_003519995.1|
Domains
11
Lj0g3v0300239.1
– PREDICTED: mRNA-decapping enzyme subunit 2-like isoform X1 [Cicer arietinum] gi|502169822|ref|XP_004514693.1|
Domains
14
Lj0g3v0331419.2
– PREDICTED: nudix hydrolase 14, chloroplastic-like [Glycine max] gi|356513721|ref|XP_003525559.1|
Domains
9
Lj0g3v0334059.1
– PREDICTED: nudix hydrolase 19, chloroplastic-like [Glycine max] gi|356514398|ref|XP_003525893.1|
Domains
13
Lj0g3v0334059.2
– PREDICTED: nudix hydrolase 19, chloroplastic-like [Glycine max] gi|356514398|ref|XP_003525893.1|
Domains
13
Lj0g3v0357479.1
– PREDICTED: nudix hydrolase 20, chloroplastic-like [Cicer arietinum] gi|502163782|ref|XP_004512948.1|
Domains
8
Lj1g3v3930310.1
– PREDICTED: nudix hydrolase 12, mitochondrial-like isoform X2 [Cicer arietinum] gi|502106928|ref|XP_004493101.1|
Domains
12
Lj1g3v3930310.2
– PREDICTED: nudix hydrolase 12, mitochondrial-like isoform X2 [Cicer arietinum] gi|502106928|ref|XP_004493101.1|
Domains
11
Lj1g3v4327730.1
– PREDICTED: nudix hydrolase 23, chloroplastic-like [Cicer arietinum] gi|502109215|ref|XP_004493593.1|
Domains
13
Lj2g3v0125090.1
– PREDICTED: nudix hydrolase 25-like [Glycine max] gi|356530740|ref|XP_003533938.1|
Domains
15
Lj2g3v0658260.1
– PREDICTED: nudix hydrolase 4 [Glycine max] gi|356531134|ref|XP_003534133.1|
Domains
11
Lj2g3v1989220.1
– PREDICTED: nudix hydrolase 8-like [Glycine max] gi|356540550|ref|XP_003538751.1|
Domains
13
Lj2g3v1989220.2
– PREDICTED: nudix hydrolase 8-like [Glycine max] gi|356540550|ref|XP_003538751.1|
Domains
17
Lj2g3v1989220.3
– PREDICTED: deSI-like protein At4g17486-like isoform X1 [Cicer arietinum] gi|502160360|ref|XP_004511719.1|
Domains
17
Lj3g3v1907670.1
– PREDICTED: nudix hydrolase 16, mitochondrial-like [Glycine max] gi|356548857|ref|XP_003542815.1|
Domains
11
Lj3g3v3213220.3
– Nudix hydrolase [Medicago truncatula] gi|357472597|ref|XP_003606583.1|
Domains
8
Lj4g3v0109380.1
– PREDICTED: nudix hydrolase 2-like [Glycine max] gi|356532784|ref|XP_003534950.1|
Domains
12
Lj4g3v0496540.1
– PREDICTED: nudix hydrolase 15, mitochondrial-like [Cicer arietinum] gi|502142845|ref|XP_004505126.1|
Domains
10
Lj4g3v0496540.2
– PREDICTED: nudix hydrolase 15, mitochondrial-like isoform 1 [Glycine max] gi|356548635|ref|XP_003542706.1|
Domains
10
Lj4g3v1865760.1
– Nudix hydrolase [Medicago truncatula] gi|357477993|ref|XP_003609282.1|
Domains
17
Lj4g3v1865760.3
– Nudix hydrolase [Medicago truncatula] gi|357477993|ref|XP_003609282.1|
Domains
17
Lj4g3v3113010.1
– PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356513062|ref|XP_003525233.1|
Domains
11
Lj5g3v1697790.1
– PREDICTED: nudix hydrolase 26, chloroplastic-like isoform X2 [Cicer arietinum] gi|502118121|ref|XP_004496111.1|
Domains
15
Lj5g3v2013890.1
– PREDICTED: LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 5-like [Glycine max] gi|356535879|ref|XP_003536470.1|
Domains
9
Lj6g3v0214770.1
– PREDICTED: nudix hydrolase 2-like [Cicer arietinum] gi|502134634|ref|XP_004502189.1|
Domains
19
Lj6g3v0340630.1
– PREDICTED: nudix hydrolase 4 [Glycine max] gi|356531134|ref|XP_003534133.1|
Domains
11
Lj6g3v0410600.1
– Nudix hydrolase [Medicago truncatula] gi|357460851|ref|XP_003600707.1|
Domains
17
Lj6g3v0739980.1
– PREDICTED: nudix hydrolase 2-like [Glycine max] gi|356524366|ref|XP_003530800.1|
Domains
19
Lj6g3v1008150.1
– PREDICTED: nudix hydrolase 3-like [Cicer arietinum] gi|502126785|ref|XP_004499436.1|
Domains
10
Lj6g3v2006030.1
– Nudix hydrolase [Medicago truncatula] gi|357446879|ref|XP_003593715.1|
Domains
13
LotjaGi1g1v0005100.1
– Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I1M666|I1M666_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0005100
Domains
16
LotjaGi1g1v0095300.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|A0A151RI97|A0A151RI97_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0095300
Domains
11
LotjaGi1g1v0200500.1
– Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|A0A151UGE9|A0A151UGE9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0200500
Domains
18
LotjaGi1g1v0485600.1
– Isopentenyl-diphosphate delta-isomerase; TAIR: AT3G02780.1 isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2; Swiss-Prot: sp|O48965|IDI2_CAMAC Isopentenyl-diphosphate Delta-isomerase II; TrEMBL-Plants: tr|A0A0S3RSE2|A0A0S3RSE2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485600
Domains
16
LotjaGi1g1v0636000.1
– Nudix hydrolase-like protein; TAIR: AT1G12880.1 nudix hydrolase homolog 12; Swiss-Prot: sp|Q93ZY7|NUD12_ARATH Nudix hydrolase 12, mitochondrial; TrEMBL-Plants: tr|I3T351|I3T351_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0636000
Domains
12
LotjaGi1g1v0726600.1
– Nudix hydrolase-like protein; TAIR: AT2G42070.1 nudix hydrolase homolog 23; Swiss-Prot: sp|P93740|NUD23_ARATH Nudix hydrolase 23, chloroplastic; TrEMBL-Plants: tr|I3SGQ4|I3SGQ4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0726600
Domains
13
LotjaGi1g1v0726600.2
– Nudix hydrolase-like protein; TAIR: AT2G42070.1 nudix hydrolase homolog 23; Swiss-Prot: sp|P93740|NUD23_ARATH Nudix hydrolase 23, chloroplastic; TrEMBL-Plants: tr|I3SGQ4|I3SGQ4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0726600
Domains
13
LotjaGi2g1v0063200.1
– RNA pyrophosphohydrolase; TAIR: AT1G30110.1 nudix hydrolase homolog 25; Swiss-Prot: sp|Q9C6Z2|NUD25_ARATH Nudix hydrolase 25; TrEMBL-Plants: tr|I3T716|I3T716_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0063200
Domains
15
LotjaGi2g1v0070200.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|A0A151QZU3|A0A151QZU3_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0070200
Domains
11
LotjaGi2g1v0119900.1
– MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|A0A0L9TCG1|A0A0L9TCG1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119900
Domains
17
LotjaGi2g1v0119900.3
– MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|A0A0L9TCG1|A0A0L9TCG1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119900
Domains
17
LotjaGi2g1v0119900.5
– MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|C6TF29|C6TF29_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0119900
Domains
17
LotjaGi2g1v0193100.1
– Nudix hydrolase-like protein; TAIR: AT1G18300.1 nudix hydrolase homolog 4; Swiss-Prot: sp|Q9LE73|NUDT4_ARATH Nudix hydrolase 4; TrEMBL-Plants: tr|I3SE70|I3SE70_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193100
Domains
11
LotjaGi2g1v0193100.2
– Nudix hydrolase-like protein; TAIR: AT1G18300.1 nudix hydrolase homolog 4; Swiss-Prot: sp|Q9LE73|NUDT4_ARATH Nudix hydrolase 4; TrEMBL-Plants: tr|I3SE70|I3SE70_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193100
Domains
11
LotjaGi2g1v0212300.1
– Nudix hydrolase 20; TAIR: AT5G19460.1 nudix hydrolase homolog 20; Swiss-Prot: sp|Q8VXZ0|NUD20_ARATH Nudix hydrolase 20, chloroplastic; TrEMBL-Plants: tr|A0A0S3TCF3|A0A0S3TCF3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0212300
Domains
18
LotjaGi2g1v0283400.1
– RNA pyrophosphohydrolase; TAIR: AT1G68760.1 nudix hydrolase 1; Swiss-Prot: sp|Q9CA40|NUDT1_ARATH Nudix hydrolase 1; TrEMBL-Plants: tr|A0A0L9UU59|A0A0L9UU59_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0283400
Domains
12
LotjaGi2g1v0367400.3
– Nudix hydrolase 9; TAIR: AT3G46200.1 nudix hydrolase homolog 9; Swiss-Prot: sp|Q8VYR2|NUDT9_ARATH Nudix hydrolase 9; TrEMBL-Plants: tr|A0A151TN32|A0A151TN32_CAJCA Nudix hydrolase 9; Found in the gene: LotjaGi2g1v0367400
Domains
7
LotjaGi2g1v0375800.1
– Nudix hydrolase 9; TAIR: AT3G46200.1 nudix hydrolase homolog 9; Swiss-Prot: sp|Q8VYR2|NUDT9_ARATH Nudix hydrolase 9; TrEMBL-Plants: tr|V7AGZ1|V7AGZ1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0375800
Domains
7
LotjaGi3g1v0108700.1
– Nudix hydrolase-like protein; TAIR: AT3G12600.1 nudix hydrolase homolog 16; Swiss-Prot: sp|Q9LHK1|NUD16_ARATH Nudix hydrolase 16, mitochondrial; TrEMBL-Plants: tr|A0A151T1U1|A0A151T1U1_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0108700
Domains
11
LotjaGi3g1v0317100.1
– Nudix hydrolase-like protein; TAIR: AT3G12600.1 nudix hydrolase homolog 16; Swiss-Prot: sp|Q9LHK1|NUD16_ARATH Nudix hydrolase 16, mitochondrial; TrEMBL-Plants: tr|I3T356|I3T356_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0317100
Domains
11
LotjaGi4g1v0006000.1
– Nudix hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I3SKF0|I3SKF0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0006000
Domains
16
LotjaGi4g1v0065600.1
– Nudix hydrolase homolog 15; TAIR: AT1G28960.1 nudix hydrolase homolog 15; Swiss-Prot: sp|Q8GYB1|NUD15_ARATH Nudix hydrolase 15, mitochondrial; TrEMBL-Plants: tr|A0A072UNI2|A0A072UNI2_MEDTR Nudix hydrolase-like protein; Found in the gene: LotjaGi4g1v0065600
Domains
13
LotjaGi4g1v0199700.1
– Nudix family hydrolase; TAIR: AT5G47240.1 nudix hydrolase homolog 8; Swiss-Prot: sp|Q8L7W2|NUDT8_ARATH Nudix hydrolase 8; TrEMBL-Plants: tr|G7JHP2|G7JHP2_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0199700
Domains
16
LotjaGi4g1v0210600.1
– Nudix hydrolase-like protein; TAIR: AT4G11980.1 nudix hydrolase homolog 14; Swiss-Prot: sp|Q9SZ63|NUD14_ARATH Nudix hydrolase 14, chloroplastic; TrEMBL-Plants: tr|A0A0L9TQC6|A0A0L9TQC6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0210600
Domains
9
LotjaGi4g1v0268700.1
– Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|G7JVC3|G7JVC3_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0268700
Domains
18
LotjaGi4g1v0268700.2
– Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|G7JVC3|G7JVC3_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0268700
Domains
18
LotjaGi4g1v0456400.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|I3S2L4|I3S2L4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0456400
Domains
11
LotjaGi5g1v0255500.1
– RNA pyrophosphohydrolase; TAIR: AT3G10620.1 nudix hydrolase homolog 26; Swiss-Prot: sp|Q9CAF2|NUD26_ARATH Nudix hydrolase 26, chloroplastic; TrEMBL-Plants: tr|I3T6R0|I3T6R0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0255500
Domains
15
LotjaGi5g1v0301800.1
– Cleavage and polyadenylation specificity factor subunit 5; TAIR: AT4G25550.1 Cleavage/polyadenylation specificity factor, 25kDa subunit; Swiss-Prot: sp|Q8GXS3|CFIS2_ARATH Pre-mRNA cleavage factor Im 25 kDa subunit 2; TrEMBL-Plants: tr|A0A0L9VEN5|A0A0L9VEN5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0301800
Domains
10
LotjaGi6g1v0024100.1
– Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I1NDT8|I1NDT8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0024100
Domains
16
LotjaGi6g1v0024100.2
– Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|G7J8V6|G7J8V6_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi6g1v0024100
Domains
23
LotjaGi6g1v0055500.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|I3SJG4|I3SJG4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0055500
Domains
17
LotjaGi6g1v0142600.1
– Nudix family hydrolase; TAIR: AT4G25434.10 nudix hydrolase homolog 10; Swiss-Prot: sp|Q6NPD7|NUD10_ARATH Nudix hydrolase 10; TrEMBL-Plants: tr|A0A0L9VBB2|A0A0L9VBB2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0142600
Domains
22
LotjaGi6g1v0187500.1
– Isopentenyl-diphosphate delta-isomerase; TAIR: AT1G79690.1 nudix hydrolase homolog 3; Swiss-Prot: sp|Q8L831|NUDT3_ARATH Nudix hydrolase 3; TrEMBL-Plants: tr|V7BM98|V7BM98_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0187500
Domains
11
LotjaGi6g1v0325300.1
– Nudix hydrolase-like protein; TAIR: AT1G28960.1 nudix hydrolase homolog 15; Swiss-Prot: sp|Q8GYB1|NUD15_ARATH Nudix hydrolase 15, mitochondrial; TrEMBL-Plants: tr|I3SCX5|I3SCX5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0325300
Domains
12
LotjaGi6g1v0325400.1
– Nudix hydrolase-like protein; TAIR: AT1G28960.1 nudix hydrolase homolog 15; Swiss-Prot: sp|Q8GYB1|NUD15_ARATH Nudix hydrolase 15, mitochondrial; TrEMBL-Plants: tr|I3SCX5|I3SCX5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0325400
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03426 CDD 1 1.41