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IPR015797

Description

IPR015797 is a NUDIX hydrolase-like domain superfamily.

<p>MutT is a small bacterial protein (~12-15Kd) involved in the GO system [[cite:PUB00002202]] responsible for removing an oxidatively damaged form of guanine (8-hydroxy-guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency, leading to A-T to G-C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate, with the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic, viral and eukaryotic proteins [[cite:PUB00004433], [cite:PUB00003856], [cite:PUB00002808], [cite:PUB00006677]].</p> <p>The generic name 'NUDIX hydrolases' (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain superfamily [[cite:PUB00006662]]. The superfamily can be divided into a number of subgroups, of which MutT anti-mutagenic activity represents only one type; most of the rest hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose, GDP-mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP).</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

Associated Lotus transcripts 83

Transcript Name Description Predicted domains Domain count
PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356553271|ref|XP_003544981.1| 11
Nudix hydrolase [Medicago truncatula] gi|357476761|ref|XP_003608666.1| 12
Nudix hydrolase [Medicago truncatula] gi|357476761|ref|XP_003608666.1| 13
Nudix hydrolase [Medicago truncatula] gi|357500493|ref|XP_003620535.1| 17
PREDICTED: nudix hydrolase 16, mitochondrial-like [Glycine max] gi|356556803|ref|XP_003546710.1| 11
PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356502376|ref|XP_003519995.1| 11
PREDICTED: mRNA-decapping enzyme subunit 2-like isoform X1 [Cicer arietinum] gi|502169822|ref|XP_004514693.1| 14
PREDICTED: nudix hydrolase 14, chloroplastic-like [Glycine max] gi|356513721|ref|XP_003525559.1| 8
PREDICTED: nudix hydrolase 14, chloroplastic-like [Glycine max] gi|356513721|ref|XP_003525559.1| 9
PREDICTED: nudix hydrolase 19, chloroplastic-like [Glycine max] gi|356514398|ref|XP_003525893.1| 13
PREDICTED: nudix hydrolase 19, chloroplastic-like [Glycine max] gi|356514398|ref|XP_003525893.1| 13
PREDICTED: nudix hydrolase 20, chloroplastic-like [Cicer arietinum] gi|502163782|ref|XP_004512948.1| 8
4
Os06g0712200 [Oryza sativa Japonica Group] gi|115469912|ref|NP_001058555.1| 4
Isopentenyl pyrophosphate isomerase [Pueraria montana var]. lobata] gi|35186998|gb|AAQ84167.1| 12
PREDICTED: nudix hydrolase 12, mitochondrial-like isoform X2 [Cicer arietinum] gi|502106928|ref|XP_004493101.1| 12
PREDICTED: nudix hydrolase 12, mitochondrial-like isoform X2 [Cicer arietinum] gi|502106928|ref|XP_004493101.1| 11
PREDICTED: nudix hydrolase 23, chloroplastic-like [Cicer arietinum] gi|502109215|ref|XP_004493593.1| 13
PREDICTED: nudix hydrolase 25-like [Glycine max] gi|356530740|ref|XP_003533938.1| 15
PREDICTED: nudix hydrolase 4 [Glycine max] gi|356531134|ref|XP_003534133.1| 11
PREDICTED: nudix hydrolase 1-like [Glycine max] gi|356496014|ref|XP_003516865.1| 5
PREDICTED: nudix hydrolase 8-like [Glycine max] gi|356540550|ref|XP_003538751.1| 13
PREDICTED: nudix hydrolase 8-like [Glycine max] gi|356540550|ref|XP_003538751.1| 17
PREDICTED: deSI-like protein At4g17486-like isoform X1 [Cicer arietinum] gi|502160360|ref|XP_004511719.1| 17
PREDICTED: nudix hydrolase 16, mitochondrial-like [Glycine max] gi|356548857|ref|XP_003542815.1| 11
PREDICTED: A/G-specific adenine DNA glycosylase-like isoform X2 [Cicer arietinum] gi|502157006|ref|XP_004510726.1| 17
PREDICTED: A/G-specific adenine DNA glycosylase-like isoform X1 [Cicer arietinum] gi|502157003|ref|XP_004510725.1| 17
Nudix hydrolase [Medicago truncatula] gi|357472597|ref|XP_003606583.1| 6
Nudix hydrolase [Medicago truncatula] gi|357472597|ref|XP_003606583.1| 5
Nudix hydrolase [Medicago truncatula] gi|357472597|ref|XP_003606583.1| 8
PREDICTED: nudix hydrolase 2-like [Glycine max] gi|356532784|ref|XP_003534950.1| 12
PREDICTED: nudix hydrolase 15, mitochondrial-like [Cicer arietinum] gi|502142845|ref|XP_004505126.1| 10
PREDICTED: nudix hydrolase 15, mitochondrial-like isoform 1 [Glycine max] gi|356548635|ref|XP_003542706.1| 10
Nudix hydrolase [Medicago truncatula] gi|357477993|ref|XP_003609282.1| 17
Nudix hydrolase [Medicago truncatula] gi|357477993|ref|XP_003609282.1| 17
PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356513062|ref|XP_003525233.1| 11
PREDICTED: nudix hydrolase 26, chloroplastic-like isoform X2 [Cicer arietinum] gi|502118121|ref|XP_004496111.1| 15
PREDICTED: LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 5-like [Glycine max] gi|356535879|ref|XP_003536470.1| 9
PREDICTED: nudix hydrolase 2-like [Cicer arietinum] gi|502134634|ref|XP_004502189.1| 19
PREDICTED: nudix hydrolase 4 [Glycine max] gi|356531134|ref|XP_003534133.1| 11
Nudix hydrolase [Medicago truncatula] gi|357460851|ref|XP_003600707.1| 17
PREDICTED: nudix hydrolase 2-like [Glycine max] gi|356524366|ref|XP_003530800.1| 19
PREDICTED: nudix hydrolase 3-like [Cicer arietinum] gi|502126785|ref|XP_004499436.1| 10
Nudix hydrolase [Medicago truncatula] gi|357446879|ref|XP_003593715.1| 13
Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I1M666|I1M666_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0005100 16
Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|A0A151RI97|A0A151RI97_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0095300 11
Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|A0A151UGE9|A0A151UGE9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0200500 18
Isopentenyl-diphosphate delta-isomerase; TAIR: AT3G02780.1 isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2; Swiss-Prot: sp|O48965|IDI2_CAMAC Isopentenyl-diphosphate Delta-isomerase II; TrEMBL-Plants: tr|A0A0S3RSE2|A0A0S3RSE2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0485600 16
Nudix hydrolase-like protein; TAIR: AT1G12880.1 nudix hydrolase homolog 12; Swiss-Prot: sp|Q93ZY7|NUD12_ARATH Nudix hydrolase 12, mitochondrial; TrEMBL-Plants: tr|I3T351|I3T351_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0636000 12
Nudix hydrolase-like protein; TAIR: AT2G42070.1 nudix hydrolase homolog 23; Swiss-Prot: sp|P93740|NUD23_ARATH Nudix hydrolase 23, chloroplastic; TrEMBL-Plants: tr|I3SGQ4|I3SGQ4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0726600 13
Nudix hydrolase-like protein; TAIR: AT2G42070.1 nudix hydrolase homolog 23; Swiss-Prot: sp|P93740|NUD23_ARATH Nudix hydrolase 23, chloroplastic; TrEMBL-Plants: tr|I3SGQ4|I3SGQ4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0726600 13
RNA pyrophosphohydrolase; TAIR: AT1G30110.1 nudix hydrolase homolog 25; Swiss-Prot: sp|Q9C6Z2|NUD25_ARATH Nudix hydrolase 25; TrEMBL-Plants: tr|I3T716|I3T716_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0063200 15
Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|A0A151QZU3|A0A151QZU3_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0070200 11
MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|A0A0L9TCG1|A0A0L9TCG1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119900 17
MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|A0A0L9TCG1|A0A0L9TCG1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119900 17
MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|C6TF29|C6TF29_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0119900 17
Nudix hydrolase-like protein; TAIR: AT1G18300.1 nudix hydrolase homolog 4; Swiss-Prot: sp|Q9LE73|NUDT4_ARATH Nudix hydrolase 4; TrEMBL-Plants: tr|I3SE70|I3SE70_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193100 11
Nudix hydrolase-like protein; TAIR: AT1G18300.1 nudix hydrolase homolog 4; Swiss-Prot: sp|Q9LE73|NUDT4_ARATH Nudix hydrolase 4; TrEMBL-Plants: tr|I3SE70|I3SE70_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193100 11
Nudix hydrolase 20; TAIR: AT5G19460.1 nudix hydrolase homolog 20; Swiss-Prot: sp|Q8VXZ0|NUD20_ARATH Nudix hydrolase 20, chloroplastic; TrEMBL-Plants: tr|A0A0S3TCF3|A0A0S3TCF3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0212300 18
RNA pyrophosphohydrolase; TAIR: AT1G68760.1 nudix hydrolase 1; Swiss-Prot: sp|Q9CA40|NUDT1_ARATH Nudix hydrolase 1; TrEMBL-Plants: tr|A0A0L9UU59|A0A0L9UU59_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0283400 12
Nudix hydrolase 9; TAIR: AT3G46200.1 nudix hydrolase homolog 9; Swiss-Prot: sp|Q8VYR2|NUDT9_ARATH Nudix hydrolase 9; TrEMBL-Plants: tr|A0A151TN32|A0A151TN32_CAJCA Nudix hydrolase 9; Found in the gene: LotjaGi2g1v0367400 7
Nudix hydrolase 9; TAIR: AT3G46200.1 nudix hydrolase homolog 9; Swiss-Prot: sp|Q8VYR2|NUDT9_ARATH Nudix hydrolase 9; TrEMBL-Plants: tr|V7AGZ1|V7AGZ1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0375800 7
Nudix hydrolase-like protein; TAIR: AT3G12600.1 nudix hydrolase homolog 16; Swiss-Prot: sp|Q9LHK1|NUD16_ARATH Nudix hydrolase 16, mitochondrial; TrEMBL-Plants: tr|A0A151T1U1|A0A151T1U1_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0108700 11
Nudix hydrolase-like protein; TAIR: AT3G12600.1 nudix hydrolase homolog 16; Swiss-Prot: sp|Q9LHK1|NUD16_ARATH Nudix hydrolase 16, mitochondrial; TrEMBL-Plants: tr|I3T356|I3T356_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0317100 11
A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|K7MEX7|K7MEX7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200 13
A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|K7KZX6|K7KZX6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200 18
A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|A0A0R0J018|A0A0R0J018_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200 18
Nudix hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I3SKF0|I3SKF0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0006000 16
Nudix hydrolase homolog 15; TAIR: AT1G28960.1 nudix hydrolase homolog 15; Swiss-Prot: sp|Q8GYB1|NUD15_ARATH Nudix hydrolase 15, mitochondrial; TrEMBL-Plants: tr|A0A072UNI2|A0A072UNI2_MEDTR Nudix hydrolase-like protein; Found in the gene: LotjaGi4g1v0065600 13
Nudix family hydrolase; TAIR: AT5G47240.1 nudix hydrolase homolog 8; Swiss-Prot: sp|Q8L7W2|NUDT8_ARATH Nudix hydrolase 8; TrEMBL-Plants: tr|G7JHP2|G7JHP2_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0199700 16
Nudix hydrolase-like protein; TAIR: AT4G11980.1 nudix hydrolase homolog 14; Swiss-Prot: sp|Q9SZ63|NUD14_ARATH Nudix hydrolase 14, chloroplastic; TrEMBL-Plants: tr|A0A0L9TQC6|A0A0L9TQC6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0210600 9
Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|G7JVC3|G7JVC3_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0268700 18
Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|G7JVC3|G7JVC3_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0268700 18
Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|I3S2L4|I3S2L4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0456400 11
RNA pyrophosphohydrolase; TAIR: AT3G10620.1 nudix hydrolase homolog 26; Swiss-Prot: sp|Q9CAF2|NUD26_ARATH Nudix hydrolase 26, chloroplastic; TrEMBL-Plants: tr|I3T6R0|I3T6R0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0255500 15
Cleavage and polyadenylation specificity factor subunit 5; TAIR: AT4G25550.1 Cleavage/polyadenylation specificity factor, 25kDa subunit; Swiss-Prot: sp|Q8GXS3|CFIS2_ARATH Pre-mRNA cleavage factor Im 25 kDa subunit 2; TrEMBL-Plants: tr|A0A0L9VEN5|A0A0L9VEN5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0301800 10
Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I1NDT8|I1NDT8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0024100 16
Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|G7J8V6|G7J8V6_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi6g1v0024100 23
Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|I3SJG4|I3SJG4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0055500 17
Nudix family hydrolase; TAIR: AT4G25434.10 nudix hydrolase homolog 10; Swiss-Prot: sp|Q6NPD7|NUD10_ARATH Nudix hydrolase 10; TrEMBL-Plants: tr|A0A0L9VBB2|A0A0L9VBB2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0142600 22
Isopentenyl-diphosphate delta-isomerase; TAIR: AT1G79690.1 nudix hydrolase homolog 3; Swiss-Prot: sp|Q8L831|NUDT3_ARATH Nudix hydrolase 3; TrEMBL-Plants: tr|V7BM98|V7BM98_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0187500 11
Nudix hydrolase-like protein; TAIR: AT1G28960.1 nudix hydrolase homolog 15; Swiss-Prot: sp|Q8GYB1|NUD15_ARATH Nudix hydrolase 15, mitochondrial; TrEMBL-Plants: tr|I3SCX5|I3SCX5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0325300 12
Nudix hydrolase-like protein; TAIR: AT1G28960.1 nudix hydrolase homolog 15; Swiss-Prot: sp|Q8GYB1|NUD15_ARATH Nudix hydrolase 15, mitochondrial; TrEMBL-Plants: tr|I3SCX5|I3SCX5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0325400 13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03426 CDD 1 1.20