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IPR013023 is a Ketol-acid reductoisomerase.
<p>Ketol-acid reductoisomerase (KARI) or acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine [[cite:PUB00001302]]. The enzyme forms a tetramer of similar but non-identical chains, and requires magnesium as a cofactor. Most ketol-acid reductoisomerases prefer the NADPH cofactor to NADH, but NADH-utilizing enzymes has also been identified [[cite:PUB00084182]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Branched-chain amino acid biosynthetic process | The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. | ||
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ketol-acid reductoisomerase [Medicago truncatula] gi|357474575|ref|XP_003607572.1| | 20 | ||
| – | Ketol-acid reductoisomerase (NADP(+)); TAIR: AT3G58610.1 ketol-acid reductoisomerase; Swiss-Prot: sp|O82043|ILV5_PEA Ketol-acid reductoisomerase, chloroplastic; TrEMBL-Plants: tr|G7JCK0|G7JCK0_MEDTR Ketol-acid reductoisomerase; Found in the gene: LotjaGi3g1v0247900 | 24 | ||
| – | Ketol-acid reductoisomerase (NADP(+)); TAIR: AT3G58610.1 ketol-acid reductoisomerase; Swiss-Prot: sp|O82043|ILV5_PEA Ketol-acid reductoisomerase, chloroplastic; TrEMBL-Plants: tr|G7JCK0|G7JCK0_MEDTR Ketol-acid reductoisomerase; Found in the gene: LotjaGi3g1v0247900 | 16 | ||
| – | Ketol-acid reductoisomerase (NADP(+)); TAIR: AT3G58610.1 ketol-acid reductoisomerase; Swiss-Prot: sp|O82043|ILV5_PEA Ketol-acid reductoisomerase, chloroplastic; TrEMBL-Plants: tr|G7JCK0|G7JCK0_MEDTR Ketol-acid reductoisomerase; Found in the gene: LotjaGi3g1v0247900 | 19 | ||
| – | Ketol-acid reductoisomerase; TAIR: AT3G58610.1 ketol-acid reductoisomerase; Swiss-Prot: sp|O82043|ILV5_PEA Ketol-acid reductoisomerase, chloroplastic; TrEMBL-Plants: tr|G7JCK0|G7JCK0_MEDTR Ketol-acid reductoisomerase; Found in the gene: LotjaGi3g1v0247900 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48179 | SUPERFAMILY | 1 | 20.00 |