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IPR013115

Source: InterPro

Description

IPR013115 is a Histidine biosynthesis HisG, C-terminal.

<p>ATP phosphoribosyltransferase ([ec:2.4.2.17]) is the enzyme that catalyzes the first step in the biosynthesis of histidine in bacteria, fungi and plants as shown below. It is a member of the larger phosphoribosyltransferase superfamily of enzymes which catalyse the condensation of 5-phospho-alpha-D-ribose 1-diphosphate with nitrogenous bases in the presence of divalent metal ions [[cite:PUB00028083]].</p> <reaction>ATP + 5-phospho-alpha-D-ribose 1-diphosphate = 1-(5-phospho-D-ribosyl)-ATP + diphosphate</reaction> <p>Histidine biosynthesis is an energetically expensive process and ATP phosphoribosyltransferase activity is subject to control at several levels. Transcriptional regulation is based primarily on nutrient conditions and determines the amount of enzyme present in the cell, while feedback inihibition rapidly modulates activity in response to cellular conditions. The enzyme has been shown to be inhibited by 1-(5-phospho-D-ribosyl)-ATP, histidine, ppGpp (a signal associated with adverse environmental conditions) and ADP and AMP (which reflect the overall energy status of the cell). As this pathway of histidine biosynthesis is present only in prokayrotes, plants and fungi, this enzyme is a promising target for the development of novel antimicrobial compounds and herbicides.</p> <p>This entry represents the C-terminal portion of ATP phosphoribosyltransferase. The enzyme itself exists in equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates [[cite:PUB00022501], [cite:PUB00028134]]. Interconversion between the various forms is largely reversible and is influenced by the binding of the natural substrates and inhibitors of the enzyme. This domain is not directly involved in catalysis but appears to be responsible for the formation of hexamers induced by the binding of inhibitors to the enzyme, thus regulating activity.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000105
Biological process Histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
Subterm of
GO:0000287
Molecular function Magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
Subterm of
GO:0003879
Molecular function ATP phosphoribosyltransferase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
Subterm of
GO:0005737
Cellular component Cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj4g3v2400820.1
– PREDICTED: ATP phosphoribosyltransferase-like [Cicer arietinum] gi|502076804|ref|XP_004485463.1|
Domains
18
LotjaGi4g1v0352800.1
– ATP phosphoribosyltransferase; TAIR: AT1G09795.1 ATP phosphoribosyl transferase 2; Swiss-Prot: sp|Q8GSJ1|HIS1B_ARATH ATP phosphoribosyltransferase 2, chloroplastic; TrEMBL-Plants: tr|A0A151T870|A0A151T870_CAJCA ATP phosphoribosyltransferase; Found in the gene: LotjaGi4g1v0352800
Domains
16
LotjaGi4g1v0352800.2
– ATP phosphoribosyltransferase; TAIR: AT1G09795.1 ATP phosphoribosyl transferase 2; Swiss-Prot: sp|Q8GSJ1|HIS1B_ARATH ATP phosphoribosyltransferase 2, chloroplastic; TrEMBL-Plants: tr|A0A067L1W5|A0A067L1W5_JATCU Uncharacterized protein; Found in the gene: LotjaGi4g1v0352800
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53850 SUPERFAMILY 1 33.33