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IPR015867 is a Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal.
<p>This entry represents a structural domain found in the nitrogen regulatory protein PII, in ATP phosphribosyltransferases (C-terminal domain), and in some bacterial hypothetical proteins. This domain consists of a ferredoxin-like α/β sandwich, which forms trimeric structures with orthogonally packed β-sheets around a three-fold axis.</p> <p>PII is a tetrameric protein encoded by glnB that functions as a component of the adenylation cascade involved in the regulation of glutamine synthetase activity [[cite:PUB00003738]]. PII helps regulate the level of glutamine synthetase in response to nitrogen source availability. In nitrogen-limiting conditions, PII is uridylylated to form PII-UMP, which allows the deadenylation of glutamine synthetase, thus activating the enzyme. Conversely, in nitrogen excess, PI-UMP is deuridylated to PII, promoting the adenylation and deactivation of glutamine synthetase [[cite:PUB00035665]].</p> <p>ATP phosphoribosyltransferase is the first enzyme of the histidine pathway. It is allosterically regulated, controlling the flow of intermediates through the pathway. The C-terminal domain is the regulatory region of the protein, which binds the allosteric inhibitor histidine [[cite:PUB00022501]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nitrogen regulatory protein P-II [Medicago truncatula] gi|357511443|ref|XP_003626010.1| | 13 | ||
| – | PREDICTED: ATP phosphoribosyltransferase-like [Cicer arietinum] gi|502076804|ref|XP_004485463.1| | 18 | ||
| – | Divalent-cation tolerance protein CutA; TAIR: AT2G33740.2 Nitrogen regulatory PII-like, alpha/beta; Swiss-Prot: sp|P93009|CUTA_ARATH Protein CutA, chloroplastic; TrEMBL-Plants: tr|G7J568|G7J568_MEDTR Divalent cation tolerance protein, CutA1 family protein; Found in the gene: LotjaGi1g1v0348600 | 16 | ||
| – | Divalent-cation tolerance protein CutA; TAIR: AT2G33740.2 Nitrogen regulatory PII-like, alpha/beta; Swiss-Prot: sp|P93009|CUTA_ARATH Protein CutA, chloroplastic; TrEMBL-Plants: tr|I3SA72|I3SA72_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0348600 | 8 | ||
| – | Nitrogen regulatory protein P-II like; TAIR: AT4G01900.1 nitrogen regulatory P-II-like protein; Swiss-Prot: sp|Q9ZST4|GLNB_ARATH Nitrogen regulatory protein P-II homolog; TrEMBL-Plants: tr|I3T553|I3T553_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0756600 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54913 | SUPERFAMILY | 1 | 20.00 |