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IPR013538 is a Activator of Hsp90 ATPase homologue 1-like, C-terminal.
<p>This entry represents a domain found in eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90kDa heat shock protein ATPase homologue 1 (AHSA1/p38, [swissprot:O95433]) and Aha1 from yeast [[cite:PUB00102522], [cite:PUB00102523]]. This is a START-like domain (also referred to as SRPBCC domain which stands for START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) which interacts with, and stabilizes the hydrophobic binding groove exposed after the interaction between the N-terminal domain of Aha1 ([interpro:IPR015310]) and the middle domain of Hsp90 [[cite:PUB00102523], [cite:PUB00102524]]. SRPBCC domains have a deep hydrophobic ligand-binding pocket. This domain is found repeated in two members of this entry ([swissprot:Q8XY04] and [swissprot:Q6MH87]).</p> <p>AHSA1/Aha1 are known to interact with the middle domain of Hsp90, and stimulate its ATPase activity [[cite:PUB00020903], [cite:PUB00102524]], one Aha1 molecule per Hsp90 dimer is sufficient for a full stimulation of Hsp90. It is probably a general up regulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress [[cite:PUB00020879]]. AHSA1 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport [[cite:PUB00020832]]. It has also been reported as being under expressed in Down's syndrome.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: activator of 90 kDa heat shock protein ATPase homolog [Cicer arietinum] gi|502122752|ref|XP_004497884.1| | 9 | ||
| – | PREDICTED: activator of 90 kDa heat shock protein ATPase homolog [Cicer arietinum] gi|502122752|ref|XP_004497884.1| | 8 | ||
| – | PREDICTED: activator of 90 kDa heat shock protein ATPase homolog [Cicer arietinum] gi|502122752|ref|XP_004497884.1| | 12 | ||
| – | Activator of 90 kDa heat shock ATPase-like protein; TAIR: AT3G12050.1 Aha1 domain-containing protein; Swiss-Prot: sp|O95433|AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1; TrEMBL-Plants: tr|A0A0B2SFA2|A0A0B2SFA2_GLYSO Activator of 90 kDa heat shock protein ATPase like 1; Found in the gene: LotjaGi1g1v0279300 | 16 | ||
| – | Activator of 90 kDa heat shock ATPase-like protein; TAIR: AT3G12050.1 Aha1 domain-containing protein; Swiss-Prot: sp|O95433|AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1; TrEMBL-Plants: tr|A0A0B2SFA2|A0A0B2SFA2_GLYSO Activator of 90 kDa heat shock protein ATPase like 1; Found in the gene: LotjaGi1g1v0279300 | 16 | ||
| – | Activator of 90 kDa heat shock ATPase; TAIR: AT3G12050.1 Aha1 domain-containing protein; Swiss-Prot: sp|Q55DB6|AHSA_DICDI Activator of 90 kDa heat shock protein ATPase homolog; TrEMBL-Plants: tr|I1N9A4|I1N9A4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0279300 | 8 | ||
| – | Activator of 90 kDa heat shock ATPase-like protein; TAIR: AT3G12050.1 Aha1 domain-containing protein; Swiss-Prot: sp|O95433|AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1; TrEMBL-Plants: tr|A0A072TGU9|A0A072TGU9_MEDTR Activator of 90 kDa heat shock ATPase-like protein; Found in the gene: LotjaGi5g1v0117100 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08892 | CDD | 1 | 14.29 |