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IPR015310 is a Activator of Hsp90 ATPase AHSA1-like, N-terminal.
<p>This entry includes a group of heat shock protein interacting proteins, including AHSA1/2 from animals and Aha1/Hch1 from budding yeasts, and it represents a domain found at the N-terminal of Aha1 and AHSA1/2, while in Hch1 is the only domain. Aha1 adopts a secondary structure consisting of an N-terminal α-helix leading into a four-stranded meandering antiparallel β-sheet, followed by a C-terminal α-helix. The two α-helices are packed together, with the β-sheet curving around them. The N-terminal domain of Aha1 interacts with the central segment of Hsp90 which induces the conformational rearrangements of Hsp90 that favor the N-terminal domain-dimerized state of the chaperone and ends leads to the stimulation of its ATPase activity [[cite:PUB00035354]].</p> <p>Activator of 90kDa heat shock protein ATPase Aha1/AHSA1 (AHSA1/p38, [swissprot:O95433]) is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity [[cite:PUB00020903], [cite:PUB00102524]], where one Aha1/AHSA1 molecule per Hsp90 dimer is sufficient for this stimulation. It is probably a general up regulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress [[cite:PUB00020879]]. It is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport [[cite:PUB00020832]]. It has also been reported as being under expressed in Down's syndrome.</p> <p>In budding yeasts, both Hch1 and Aha1 bind to the middle domain of Hsp90 and stimulate ATPase activity [[cite:PUB00020903], [cite:PUB00090459]]. However, Aha1 but not Hch1 stimulated the intrinsic ATPase activity of Hsp90 5-fold [[cite:PUB00020903]]. Hch1 and Aha1 may regulate Hsp90 function in distinct ways [[cite:PUB00020903]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATPase activator activity | Binds to and increases the ATP hydrolysis activity of an ATPase. | ||
| Molecular function | Chaperone binding | Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: activator of 90 kDa heat shock protein ATPase homolog [Cicer arietinum] gi|502122752|ref|XP_004497884.1| | 9 | ||
| – | PREDICTED: activator of 90 kDa heat shock protein ATPase homolog [Cicer arietinum] gi|502122752|ref|XP_004497884.1| | 12 | ||
| – | Chaperone binding,ATPase activators [Theobroma cacao] gi|508784952|gb|EOY32208.1| | 7 | ||
| – | Activator of 90 kDa heat shock ATPase-like protein; TAIR: AT3G12050.1 Aha1 domain-containing protein; Swiss-Prot: sp|O95433|AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1; TrEMBL-Plants: tr|A0A0B2SFA2|A0A0B2SFA2_GLYSO Activator of 90 kDa heat shock protein ATPase like 1; Found in the gene: LotjaGi1g1v0279300 | 16 | ||
| – | Activator of 90 kDa heat shock ATPase-like protein; TAIR: AT3G12050.1 Aha1 domain-containing protein; Swiss-Prot: sp|O95433|AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1; TrEMBL-Plants: tr|A0A0B2SFA2|A0A0B2SFA2_GLYSO Activator of 90 kDa heat shock protein ATPase like 1; Found in the gene: LotjaGi1g1v0279300 | 16 | ||
| – | Activator of 90 kDa heat shock ATPase; TAIR: AT5G58110.1 chaperone binding / ATPase activator; Swiss-Prot: sp|A6QQC0|AHSA2_BOVIN Activator of 90 kDa heat shock protein ATPase homolog 2; TrEMBL-Plants: tr|I3T1P8|I3T1P8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0235800 | 10 | ||
| – | Activator of 90 kDa heat shock ATPase; TAIR: AT5G58110.1 chaperone binding / ATPase activator; Swiss-Prot: sp|A6QQC0|AHSA2_BOVIN Activator of 90 kDa heat shock protein ATPase homolog 2; TrEMBL-Plants: tr|I3T1P8|I3T1P8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0235800 | 10 | ||
| – | Activator of 90 kDa heat shock ATPase; TAIR: AT5G58110.1 chaperone binding / ATPase activator; Swiss-Prot: sp|A6QQC0|AHSA2_BOVIN Activator of 90 kDa heat shock protein ATPase homolog 2; TrEMBL-Plants: tr|I3T1P8|I3T1P8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0235800 | 10 | ||
| – | Activator of 90 kDa heat shock ATPase-like protein; TAIR: AT3G12050.1 Aha1 domain-containing protein; Swiss-Prot: sp|O95433|AHSA1_HUMAN Activator of 90 kDa heat shock protein ATPase homolog 1; TrEMBL-Plants: tr|A0A072TGU9|A0A072TGU9_MEDTR Activator of 90 kDa heat shock ATPase-like protein; Found in the gene: LotjaGi5g1v0117100 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08892 | CDD | 1 | 11.11 |