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IPR013699 is a Signal recognition particle, SRP72 subunit, RNA-binding.
<p>The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [[cite:PUB00035998], [cite:PUB00028143], [cite:PUB00100261]]. SRP recognises the signal sequence of the nascent polypeptide on the ribosome. In eukaryotes this retards its elongation until SRP docks the ribosome-polypeptide complex to the RER membrane via the SR receptor [[cite:PUB00063486], [cite:PUB00100261]]. Eukaryotic SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide 7S RNA molecule. The RNA component catalyses the interaction of SRP with its SR receptor [[cite:PUB00035999]]. In higher eukaryotes, the SRP complex consists of the Alu domain and the S domain linked by the SRP RNA. The Alu domain consists of a heterodimer of SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA. This domain is necessary for retarding the elongation of the nascent polypeptide chain, which gives SRP time to dock the ribosome-polypeptide complex to the RER membrane. In archaea, the SRP complex contains 7S RNA like its eukaryotic counterpart, yet only includes two of the six protein subunits found in the eukaryotic complex: SRP19 and SRP54 [[cite:PUB00053948]].</p> <p>This entry represents the RNA binding domain of the SRP72 subunit. This domain is responsible for the binding of SRP72 to the 7S SRP RNA [[cite:PUB00020940]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | SRP-dependent cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. | ||
| Molecular function | 7S RNA binding | Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). | ||
| Cellular component | Signal recognition particle | A complex of protein and RNA which facilitates translocation of proteins across membranes. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: signal recognition particle 72 kDa protein-like [Glycine max] gi|356525126|ref|XP_003531178.1| | 12 | ||
| – | Signal recognition particle subunit SRP72; TAIR: AT1G67680.1 SRP72 RNA-binding domain-containing protein; Swiss-Prot: sp|O76094|SRP72_HUMAN Signal recognition particle subunit SRP72; TrEMBL-Plants: tr|A0A0S3R174|A0A0S3R174_PHAAN Signal recognition particle subunit SRP72; Found in the gene: LotjaGi4g1v0363300 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |