Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR014006 is a Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
<p>This entry represents the flavoprotein subunit found in both the SQR and QFR enzymes. This subunit contains an N-terminal domain which binds the FAD cofactor, a central catalytic domain with an unusual fold, and a C-terminal domain whose role is unclear [[cite:PUB00007431], [cite:PUB00028408], [cite:PUB00015752]]. The dicarboxylate binding site is located between the FAD and catalytic domains.</p> <p>Succinate:quinone oxidoreductase ([ec:1.3.5.1]) refers collectively to succinate:quinone reductase (SQR, or Complex II) and quinol:fumarate reductase (QFR) [[cite:PUB00015792]]. SQR is found in aerobic organisms, and catalyses the oxidation of succinate to fumarate in the citric acid cycle and donates the electrons to quinone in the membrane. QFR can be found in anaerobic cells respiring with fumarate as terminal electron acceptor. SQR and QFR are very similar in composition and structure, despite catalysing opposite reactions<i>in vivo</i>. They are thought to have evolved from a common ancestor, and in Escherichia coli they are capable of functionally replacing each other [[cite:PUB00033856]].</p> <p>Succinate:quinone oxidoreductases consist of a peripheral domain, exposed to the cytoplasm in bacteria and to the matrix in mitochondria, and a membrane-integral anchor domain that spans the membrane (Fig. 1). The peripheral part, which contains the dicarboxylate binding site, is composed of a flavoprotein subunit, with one covalently bound FAD, and an iron-sulphur protein subunit containing three iron-sulphur clusters. The membrane-integral domain functions to anchor the peripheral domain to the membrane and is required for quinone reduction and oxidation. The anchor domain shows the largest variability in composition and primary sequence, being composed either of one large subunit, or two smaller subunits, which may, or may not, contain protoheme groups.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity, acting on the CH-CH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. | ||
| Biological process | Electron transport chain | A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. | ||
| Molecular function | Flavin adenine dinucleotide binding | Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: succinate dehydrogenase [ubiquinone] gi|356498373|ref|XP_003518027.1| | 22 | ||
| – | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; TAIR: AT5G66760.1 succinate dehydrogenase 1-1; Swiss-Prot: sp|O82663|SDHA1_ARATH Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial; TrEMBL-Plants: tr|I1JCQ7|I1JCQ7_SOYBN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Found in the gene: LotjaGi4g1v0116700 | 23 | ||
| – | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; TAIR: AT5G66760.1 succinate dehydrogenase 1-1; Swiss-Prot: sp|O82663|SDHA1_ARATH Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial; TrEMBL-Plants: tr|I1JCQ7|I1JCQ7_SOYBN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Found in the gene: LotjaGi4g1v0116700 | 23 | ||
| – | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; TAIR: AT5G66760.1 succinate dehydrogenase 1-1; Swiss-Prot: sp|O82663|SDHA1_ARATH Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial; TrEMBL-Plants: tr|I1JCQ7|I1JCQ7_SOYBN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Found in the gene: LotjaGi4g1v0116700 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01816 | TIGRFAM | 1 | 25.00 |