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IPR014025 is a Glutaredoxin subgroup.
<p>Glutaredoxins [[cite:PUB00001738], [cite:PUB00000560], [cite:PUB00002504]], also known as thioltransferases (disulphide reductases), are small proteins of approximately one hundred amino-acid residues which utilise glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system [[cite:PUB00014033]].</p> <p>Glutaredoxin functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Like thioredoxin (TRX), which functions in a similar way, glutaredoxin possesses an active centre disulphide bond [[cite:PUB00015562]]. It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulphide bond. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. The flow of reducing equivalents in the GRX system goes from NADPH ->GSH reductase ->GSH ->GRX ->protein substrates [[cite:PUB00023503], [cite:PUB00030238], [cite:PUB00080927], [cite:PUB00080925]]. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress.</p> <p>Glutaredoxin has been sequenced in a variety of species. On the basis of extensive sequence similarity, it has been proposed [[cite:PUB00005575]] that Vaccinia virus protein O2L is most probably a glutaredoxin. Finally, it must be noted that Bacteriophage T4 thioredoxin seems also to be evolutionary related. In position 5 of the pattern T4 thioredoxin has Val instead of Pro.</p> <p>This entry represents a conserved region including the active site of this enzyme.</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | 13 | |||
– | Glutaredoxin-related protein [Arabidopsis thaliana] gi|18399411|ref|NP_566405.1| | 20 | ||
– | Glutaredoxin-related protein [Arabidopsis thaliana] gi|18399411|ref|NP_566405.1| | 16 | ||
– | PREDICTED: glutaredoxin-C1-like [Cicer arietinum] gi|502133854|ref|XP_004501914.1| | 14 | ||
– | Monothiol glutaredoxin-S2 [Medicago truncatula] gi|357478629|ref|XP_003609600.1| | 13 | ||
– | PREDICTED: glutaredoxin-C2-like [Cicer arietinum] gi|502100486|ref|XP_004491729.1| | 15 | ||
– | PREDICTED: monothiol glutaredoxin-S6-like [Glycine max] gi|356570945|ref|XP_003553643.1| | 13 | ||
– | Glutaredoxin [Phaseolus vulgaris] gi|319428667|gb|ADV56690.1| | 13 | ||
– | Glutaredoxin [Phaseolus vulgaris] gi|319428665|gb|ADV56688.1| | 13 | ||
– | PREDICTED: glutaredoxin-C3-like [Cicer arietinum] gi|502161216|ref|XP_004512079.1| | 18 | ||
– | PREDICTED: monothiol glutaredoxin-S2-like [Glycine max] gi|356563857|ref|XP_003550174.1| | 13 | ||
– | Glutaredoxin [Phaseolus vulgaris] gi|319428667|gb|ADV56690.1| | 13 | ||
– | PREDICTED: glutaredoxin-C11-like [Cicer arietinum] gi|502117880|ref|XP_004495991.1| | 13 | ||
– | PREDICTED: monothiol glutaredoxin-S2-like [Glycine max] gi|356555547|ref|XP_003546092.1| | 13 | ||
– | Glutaredoxin; TAIR: AT5G63030.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q8L8T2|GRXC1_ARATH Glutaredoxin-C1; TrEMBL-Plants: tr|I3S7F5|I3S7F5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0178600 | 12 | ||
– | Glutaredoxin; TAIR: AT5G63030.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q8L8T2|GRXC1_ARATH Glutaredoxin-C1; TrEMBL-Plants: tr|I3S7F5|I3S7F5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0178600 | 12 | ||
– | Glutaredoxin family protein; TAIR: AT5G18600.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q8L8Z8|GRXS2_ARATH Monothiol glutaredoxin-S2; TrEMBL-Plants: tr|I3SY22|I3SY22_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0562100 | 13 | ||
– | Glutaredoxin; TAIR: AT5G40370.1 Glutaredoxin family protein; Swiss-Prot: sp|P55143|GLRX_RICCO Glutaredoxin; TrEMBL-Plants: tr|I3ST16|I3ST16_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0609500 | 14 | ||
– | Glutaredoxin; TAIR: AT3G62930.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q9LYC8|GRXS6_ARATH Monothiol glutaredoxin-S6; TrEMBL-Plants: tr|I3RZX1|I3RZX1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0768200 | 13 | ||
– | Glutaredoxin; TAIR: AT3G62930.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q9LYC8|GRXS6_ARATH Monothiol glutaredoxin-S6; TrEMBL-Plants: tr|E9NZU1|E9NZU1_PHAVU Glutaredoxin; Found in the gene: LotjaGi1g1v0768300 | 13 | ||
– | Glutaredoxin; TAIR: AT3G62950.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q9LYC6|GRC11_ARATH Glutaredoxin-C11; TrEMBL-Plants: tr|E9NZT9|E9NZT9_PHAVU Glutaredoxin; Found in the gene: LotjaGi1g1v0768700 | 13 | ||
– | Glutaredoxin family protein; TAIR: AT1G77370.1 Glutaredoxin family protein; Swiss-Prot: sp|Q9FVX1|GRXC3_ARATH Glutaredoxin-C3; TrEMBL-Plants: tr|I3SW74|I3SW74_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0386400 | 20 | ||
– | Glutaredoxin family protein; TAIR: AT1G77370.1 Glutaredoxin family protein; Swiss-Prot: sp|Q9FVX1|GRXC3_ARATH Glutaredoxin-C3; TrEMBL-Plants: tr|I3SW74|I3SW74_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0386400 | 20 | ||
– | Glutaredoxin family protein; TAIR: AT5G18600.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q8L8Z8|GRXS2_ARATH Monothiol glutaredoxin-S2; TrEMBL-Plants: tr|I1MRF6|I1MRF6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0355500 | 13 | ||
– | Glutaredoxin family protein; TAIR: AT5G18600.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q8L8Z8|GRXS2_ARATH Monothiol glutaredoxin-S2; TrEMBL-Plants: tr|G7JJ49|G7JJ49_MEDTR Monothiol glutaredoxin-S2 protein; Found in the gene: LotjaGi4g1v0345500 | 13 | ||
– | Glutaredoxin family protein; TAIR: AT4G28730.1 Glutaredoxin family protein; Swiss-Prot: sp|Q8GWS0|GRXC5_ARATH Glutaredoxin-C5, chloroplastic; TrEMBL-Plants: tr|I3SBR5|I3SBR5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0150300 | 13 | ||
– | Glutaredoxin; TAIR: AT3G62950.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q9LYC6|GRC11_ARATH Glutaredoxin-C11; TrEMBL-Plants: tr|B7FMA1|B7FMA1_MEDTR Glutaredoxin-C1 protein; Found in the gene: LotjaGi5g1v0263100 | 13 | ||
– | Glutaredoxin; TAIR: AT1G03020.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q9SA68|GRXS1_ARATH Monothiol glutaredoxin-S1; TrEMBL-Plants: tr|E9NZU1|E9NZU1_PHAVU Glutaredoxin; Found in the gene: LotjaGi5g1v0263500 | 13 | ||
– | Glutaredoxin; TAIR: AT3G62930.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q9LYC8|GRXS6_ARATH Monothiol glutaredoxin-S6; TrEMBL-Plants: tr|E9NZU1|E9NZU1_PHAVU Glutaredoxin; Found in the gene: LotjaGi5g1v0263600_LC | 13 | ||
– | Glutaredoxin; TAIR: AT5G20500.1 Glutaredoxin family protein; Swiss-Prot: sp|Q8LFQ6|GRXC4_ARATH Glutaredoxin-C4; TrEMBL-Plants: tr|I3T6M7|I3T6M7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0232900 | 23 | ||
– | Glutaredoxin family protein; TAIR: AT4G15680.1 Thioredoxin superfamily protein; Swiss-Prot: sp|O23419|GRXS4_ARATH Monothiol glutaredoxin-S4; TrEMBL-Plants: tr|I3SFN5|I3SFN5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0306900 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd03419 | CDD | 1 | 3.23 |