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IPR014042

Source: InterPro

Description

IPR014042 is a Glutathione synthase, alpha-helical.

<p>This superfamily represents an α-helical domain found in glutathione synthetase ([ec:6.3.2.3]) (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase [[cite:PUB00035960]]. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004363
Molecular function Glutathione synthase activity Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0006750
Biological process Glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Subterm of
GO:0016874
Molecular function Ligase activity Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj1g3v4954990.1
– Homoglutathione synthetase [Lotus japonicus] gi|34484369|gb|AAO92441.1|
Domains
19
Lj1g3v4955000.1
– Homoglutathione synthetase [Lotus japonicus] gi|34484369|gb|AAO92441.1|
Domains
19
Lj1g3v4955040.1
– Glutathione synthetase [Lotus japonicus] gi|37222544|gb|AAK77663.2|AF279703_1
Domains
20
LotjaGi1g1v0775600.1
– Glutathione synthetase; TAIR: AT5G27380.1 glutathione synthetase 2; Swiss-Prot: sp|O23732|GSHB_BRAJU Glutathione synthetase, chloroplastic; TrEMBL-Plants: tr|Q93XE5|Q93XE5_LOTJA Glutathione synthetase; Found in the gene: LotjaGi1g1v0775600
Domains
22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 25.00