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IPR016185 is a Pre-ATP-grasp domain superfamily.
<p>The pre-ATP-grasp domain is a structural component found in many ATP-grasp enzymes. It is an N-terminal domain that precedes the core ATP-grasp fold in these proteins [[cite:PUB00057486]]. While not directly involved in ATP binding, the pre-ATP-grasp domain likely plays a role in substrate recognition and binding, contributing to the overall catalytic function of the enzymes.</p> <p>The ATP-grasp fold is one of several distinct ATP-binding folds, and is found in enzymes that catalyse the formation of amide bonds, catalysing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule [[cite:PUB00020972]]. This fold is found in many different enzyme families, including various peptide synthetases, biotin carboxylase, synapsin, succinyl-CoA synthetase, pyruvate phosphate dikinase, and glutathione synthetase, glutathionylspermidine synthase, amongst others [[cite:PUB00028114]]. These enzymes contribute predominantly to macromolecular synthesis, using ATP-hydrolysis to activate their substrates.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phosphoribosylaminoimidazole carboxylase, chloroplastic-like [Glycine max] gi|356535191|ref|XP_003536132.1| | 12 | ||
| – | PREDICTED: phosphoribosylaminoimidazole carboxylase, chloroplastic-like [Glycine max] gi|356535191|ref|XP_003536132.1| | 6 | ||
| – | D-alanine--D-alanine ligase [Medicago truncatula] gi|357506461|ref|XP_003623519.1| | 14 | ||
| – | D-alanine--D-alanine ligase [Medicago truncatula] gi|357506461|ref|XP_003623519.1| | 21 | ||
| – | D-alanine--D-alanine ligase [Medicago truncatula] gi|357506461|ref|XP_003623519.1| | 19 | ||
| – | PREDICTED: phosphoribosylaminoimidazole carboxylase, chloroplastic-like [Glycine max] gi|356535191|ref|XP_003536132.1| | 13 | ||
| – | Carbamoyl-phosphate synthase large chain [Medicago truncatula] gi|357453751|ref|XP_003597156.1| | 32 | ||
| – | PREDICTED: phosphoribosylaminoimidazole carboxylase, chloroplastic-like [Glycine max] gi|356535191|ref|XP_003536132.1| | 30 | ||
| – | PREDICTED: phosphoribosylaminoimidazole carboxylase, chloroplastic-like [Glycine max] gi|356535191|ref|XP_003536132.1| | 5 | ||
| – | D-alanine--D-alanine ligase [Medicago truncatula] gi|357506461|ref|XP_003623519.1| | 22 | ||
| – | D-alanine--D-alanine ligase [Medicago truncatula] gi|357506461|ref|XP_003623519.1| | 21 | ||
| – | Homoglutathione synthetase [Lotus japonicus] gi|34484369|gb|AAO92441.1| | 19 | ||
| – | Homoglutathione synthetase [Lotus japonicus] gi|34484369|gb|AAO92441.1| | 19 | ||
| – | Glutathione synthetase [Lotus japonicus] gi|37222544|gb|AAK77663.2|AF279703_1 | 20 | ||
| – | PREDICTED: biotin carboxylase 1, chloroplastic-like [Cicer arietinum] gi|502138858|ref|XP_004503555.1| | 26 | ||
| – | PREDICTED: methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial-like isoform X2 [Cicer arietinum] gi|502115337|ref|XP_004495179.1| | 33 | ||
| – | PREDICTED: phosphoribosylamine--glycine ligase, chloroplastic-like isoform X2 [Cicer arietinum] gi|502123844|ref|XP_004498282.1| | 28 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|A0A0R0K6S7|A0A0R0K6S7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|A0A0R0K6S7|A0A0R0K6S7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|I1JVH6|I1JVH6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | Acetyl-CoA carboxylase; TAIR: AT1G36160.1 acetyl-CoA carboxylase 1; Swiss-Prot: sp|Q38970|ACC1_ARATH Acetyl-CoA carboxylase 1; TrEMBL-Plants: tr|A0A0R0K6S7|A0A0R0K6S7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0246300 | 46 | ||
| – | D-alanine--D-alanine ligase; TAIR: AT3G08840.2 D-alanine-D-alanine ligase family; Swiss-Prot: sp|Q6MQ94|DDL_BDEBA D-alanine--D-alanine ligase; TrEMBL-Plants: tr|I1L754|I1L754_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0450300 | 21 | ||
| – | Glutathione synthetase; TAIR: AT5G27380.1 glutathione synthetase 2; Swiss-Prot: sp|O23732|GSHB_BRAJU Glutathione synthetase, chloroplastic; TrEMBL-Plants: tr|Q93XE5|Q93XE5_LOTJA Glutathione synthetase; Found in the gene: LotjaGi1g1v0775600 | 22 | ||
| – | Carbamoyl-phosphate synthase large chain; TAIR: AT1G29900.1 carbamoyl phosphate synthetase B; Swiss-Prot: sp|Q42601|CARB_ARATH Carbamoyl-phosphate synthase large chain, chloroplastic; TrEMBL-Plants: tr|G7IU57|G7IU57_MEDTR Carbamoyl-phosphate synthase large chain; Found in the gene: LotjaGi3g1v0161000 | 36 | ||
| – | Biotin carboxylase; TAIR: AT5G35360.1 acetyl Co-enzyme a carboxylase biotin carboxylase subunit; Swiss-Prot: sp|B9HBA8|ACCC1_POPTR Biotin carboxylase 1, chloroplastic; TrEMBL-Plants: tr|O23960|O23960_SOYBN Acetyl-CoA carboxylase; Found in the gene: LotjaGi4g1v0439600 | 23 | ||
| – | Biotin carboxylase; TAIR: AT5G35360.1 acetyl Co-enzyme a carboxylase biotin carboxylase subunit; Swiss-Prot: sp|B9HBA8|ACCC1_POPTR Biotin carboxylase 1, chloroplastic; TrEMBL-Plants: tr|O23960|O23960_SOYBN Acetyl-CoA carboxylase; Found in the gene: LotjaGi4g1v0439600 | 23 | ||
| – | Acetyl-CoA carboxylase, putative; TAIR: AT1G03090.2 methylcrotonyl-CoA carboxylase alpha chain; Swiss-Prot: sp|Q42777|MCCA_SOYBN Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; TrEMBL-Plants: tr|A0A151QXF8|A0A151QXF8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi5g1v0170200 | 30 | ||
| – | Formate-dependent phosphoribosylglycinamide formyltransferase; TAIR: AT2G37690.1 phosphoribosylaminoimidazole carboxylase, putative / AIR carboxylase; Swiss-Prot: sp|P55195|PUR6_VIGAC Phosphoribosylaminoimidazole carboxylase, chloroplastic; TrEMBL-Plants: tr|K7LJS8|K7LJS8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0211000 | 32 | ||
| – | Phosphoribosylamine-glycine ligase; TAIR: AT1G09830.1 Glycinamide ribonucleotide (GAR) synthetase; Swiss-Prot: sp|P52420|PUR2_ARATH Phosphoribosylamine--glycine ligase, chloroplastic; TrEMBL-Plants: tr|K7LJM6|K7LJM6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0354900 | 28 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00877 | TIGRFAM | 1 | 3.45 |