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IPR014709 is a Glutathione synthase, C-terminal, eukaryotic.
<p>This superfamily represents the C-terminal domain found in eukaryotic glutathione synthetase ([ec:6.3.2.3]) (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase [[cite:PUB00035960]]. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system.</p> <p>This domain has a 2-layer α/β structure.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Homoglutathione synthetase [Lotus japonicus] gi|34484369|gb|AAO92441.1| | 19 | ||
| – | Homoglutathione synthetase [Lotus japonicus] gi|34484369|gb|AAO92441.1| | 19 | ||
| – | Glutathione synthetase [Lotus japonicus] gi|37222544|gb|AAK77663.2|AF279703_1 | 20 | ||
| – | Glutathione synthetase; TAIR: AT5G27380.1 glutathione synthetase 2; Swiss-Prot: sp|O23732|GSHB_BRAJU Glutathione synthetase, chloroplastic; TrEMBL-Plants: tr|Q93XE5|Q93XE5_LOTJA Glutathione synthetase; Found in the gene: LotjaGi1g1v0775600 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |