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IPR014762 is a DNA mismatch repair, conserved site.
<p>Mismatch repair contributes to the overall fidelity of DNA replication [[cite:PUB00000050]]. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The sequence of some proteins involved in mismatch repair in different organisms have been found to be evolutionarily related. These proteins include:</p> <ul> <li>Escherichia coli and Salmonella typhimurium mutL protein [[cite:PUB00002089]]. MutL is required for dam-dependent methyl-directed DNA repair.</li> <li>Streptococcus pneumoniae hexB protein [[cite:PUB00002090]]. The Hex system is nick directed.</li> <li>Yeast proteins PMS1 and MLH1 [[cite:PUB00003695]].</li> <li>Human protein MLH1 [[cite:PUB00004174]] which is involved in a form of familial hereditary nonpolyposis colon cancer (HNPCC).</li> </ul> <p>This entry represents a perfectly conserved heptapeptide which is located in the N-terminal section of these proteins.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA mismatch repair protein Mlh1-like [Glycine max] gi|356507690|ref|XP_003522597.1| | 15 | ||
| – | MutL DNA mismatch repair protein [Medicago truncatula] gi|357484163|ref|XP_003612368.1| | 10 | ||
| – | PREDICTED: DNA mismatch repair protein MLH1-like [Cicer arietinum] gi|502127149|ref|XP_004499581.1| | 21 | ||
| – | DNA mismatch repair protein mutL; TAIR: AT4G35520.2 MUTL protein homolog 3; Swiss-Prot: sp|F4JN26|MLH3_ARATH DNA mismatch repair protein MLH3; TrEMBL-Plants: tr|A0A0B2RU55|A0A0B2RU55_GLYSO DNA mismatch repair protein Mlh3; Found in the gene: LotjaGi2g1v0354500 | 30 | ||
| – | DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500 | 22 | ||
| – | DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500 | 22 | ||
| – | MutL DNA mismatch repair protein; TAIR: AT4G02460.1 DNA mismatch repair protein; Swiss-Prot: sp|Q941I6|PMS1_ARATH DNA mismatch repair protein PMS1; TrEMBL-Plants: tr|I1JFI1|I1JFI1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0251500 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |