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IPR002099 is a DNA mismatch repair protein MutL/Mlh/PMS.
<p>This entry represents DNA mismatch repair proteins including bacterial MutL and its homologues from eukaryotes. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [[cite:PUB00088630], [cite:PUB00063184], [cite:PUB00106850]]. MutL proteins and their homologues share sequence homology at their N termini over the first 300-400 residues; the C termini are less well conserved, they constitute the main dimerization domain and are required for interaction between MutL and UvrD helicase [[cite:PUB00088622]]. The activity of the protein is modulated by the ATP-dependent dimerization of the N-terminal domain [[cite:PUB00020814]].</p> <p>The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [[cite:PUB00020815]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | ||
| Molecular function | Mismatched DNA binding | Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA mismatch repair protein Mlh1-like [Glycine max] gi|356507690|ref|XP_003522597.1| | 15 | ||
| – | PREDICTED: DNA mismatch repair protein MLH1-like [Cicer arietinum] gi|502127149|ref|XP_004499581.1| | 21 | ||
| – | DNA mismatch repair protein mutL; TAIR: AT4G35520.2 MUTL protein homolog 3; Swiss-Prot: sp|F4JN26|MLH3_ARATH DNA mismatch repair protein MLH3; TrEMBL-Plants: tr|A0A0B2RU55|A0A0B2RU55_GLYSO DNA mismatch repair protein Mlh3; Found in the gene: LotjaGi2g1v0354500 | 30 | ||
| – | DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500 | 22 | ||
| – | DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500 | 22 | ||
| – | MutL DNA mismatch repair protein; TAIR: AT4G02460.1 DNA mismatch repair protein; Swiss-Prot: sp|Q941I6|PMS1_ARATH DNA mismatch repair protein PMS1; TrEMBL-Plants: tr|I1JFI1|I1JFI1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0251500 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |