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IPR038973 is a DNA mismatch repair protein MutL/Mlh/Pms-like.
<p>Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [[cite:PUB00020815]]. This entry represents a family of evolutionarily related DNA mismatch repair proteins, including MutL, Mlh1, Mlh2 and Mlh3, and Pms 1 and 2. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [[cite:PUB00088630], [cite:PUB00063184], [cite:PUB00106850]]. MutL homologues share a conserved ATP binding site [[cite:PUB00088631]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | ||
| Molecular function | ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. | ||
| Cellular component | Mismatch repair complex | Any complex formed of proteins that act in mismatch repair. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA mismatch repair protein mutL; TAIR: AT4G35520.2 MUTL protein homolog 3; Swiss-Prot: sp|F4JN26|MLH3_ARATH DNA mismatch repair protein MLH3; TrEMBL-Plants: tr|A0A0B2RU55|A0A0B2RU55_GLYSO DNA mismatch repair protein Mlh3; Found in the gene: LotjaGi2g1v0354500 | 30 | ||
| – | DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500 | 22 | ||
| – | DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500 | 22 | ||
| – | MutL DNA mismatch repair protein; TAIR: AT4G02460.1 DNA mismatch repair protein; Swiss-Prot: sp|Q941I6|PMS1_ARATH DNA mismatch repair protein PMS1; TrEMBL-Plants: tr|I1JFI1|I1JFI1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0251500 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |