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IPR037198 is a MutL, C-terminal domain superfamily.
<p>MutL and MutS are key components of the DNA repair machinery that corrects replication errors [[cite:PUB00035423]]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair. The N-terminal region of MutL contains the ATPase domain and the C-terminal is involved in dimerisation [[cite:PUB00032360]].</p> <p>The structure of the C-terminal domain of MutL consists of two different α+β (sub)domains, both composed of two layers (α/β) with antiparallel sheet, where the second domain is inserted in the first one.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA mismatch repair protein mutL; TAIR: AT4G35520.2 MUTL protein homolog 3; Swiss-Prot: sp|F4JN26|MLH3_ARATH DNA mismatch repair protein MLH3; TrEMBL-Plants: tr|A0A0B2RU55|A0A0B2RU55_GLYSO DNA mismatch repair protein Mlh3; Found in the gene: LotjaGi2g1v0354500 | 30 | ||
| – | MutL DNA mismatch repair protein; TAIR: AT4G02460.1 DNA mismatch repair protein; Swiss-Prot: sp|Q941I6|PMS1_ARATH DNA mismatch repair protein PMS1; TrEMBL-Plants: tr|I1JFI1|I1JFI1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0251500 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |