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IPR015320

Source: InterPro

Description

IPR015320 is a DNA topoisomerase VI, subunit B, transducer.

<p>DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [[cite:PUB00005437]]. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [[cite:PUB00020794], [cite:PUB00016842]]. DNA topoisomerases are divided into two classes: type I enzymes ([ec:5.6.2.2]; topoisomerases I, III and V) break single-strand DNA, and type II enzymes ([ec:5.6.2.2]; topoisomerases II, IV and VI) break double-strand DNA [[cite:PUB00020793]].</p> <p>Type II topoisomerases are ATP-dependent enzymes, and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils [[cite:PUB00020795]].</p> <p>This entry represents subunit B of topoisomerase VI, an ATP-dependent type IIB enzyme. Members of this family adopt a structure consisting of a four-stranded β-sheet backed by three α-helices, the last of which is over 50 amino acids long and extends from the body of the protein by several turns. This domain has been proposed to mediate intersubunit communication by structurally transducing signals from the ATP binding and hydrolysis domains to the DNA binding and cleavage domains of the gyrase holoenzyme [[cite:PUB00014011]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003677
Molecular function DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
Subterm of
GO:0003918
Molecular function DNA topoisomerase type II (ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Subterm of
GO:0006265
Biological process DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0293000.1
– DNA topoisomerase 6 subunit B; TAIR: AT3G20780.1 topoisomerase 6 subunit B; Swiss-Prot: sp|Q9C5V6|TOP6B_ARATH DNA topoisomerase 6 subunit B; TrEMBL-Plants: tr|I1M541|I1M541_SOYBN DNA topoisomerase 6 subunit B; Found in the gene: LotjaGi3g1v0293000
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00