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IPR015412

Source: InterPro

Description

IPR015412 is a Atg2/VPS13, C-terminal.

<p>Eukaryotes have developed an evolutionarily conserved process, termed autophagy, to survive starvation conditions. The vacuole or lysosome mediates the turnover and recycling of non-essential intracellular material for re-use in critical biosynthetic reactions. ATG2 (also known as Apg2) is required for the formation and/or completion of cytosolic sequestering vesicles that are needed for vacuolar import through both the Cvt pathway and autophagy, as well as for the specific degradation of peroxisomes. ATG2 is a peripheral membrane protein that localises to the previously identified perivacuolar compartment that contains Apg9 [[cite:PUB00035359]].</p> <p>This entry represents the C-terminal domain of ATG2 and related proteins such as VPS13, which contains two to three predicted amphipathic helices (AHs) that anchors these proteins to mitochondria, late endosomes or lipid droplets [[cite:PUB00101955], [cite:PUB00100769], [cite:PUB00100859], [cite:PUB00100863]]. This domain is required for membrane recruitment and localisation [[cite:PUB00101955]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj0g3v0126289.1
– Autophagy-related protein 2 [Arabidopsis thaliana] gi|316995369|gb|ADU79134.1|
Domains
5
Lj0g3v0313759.1
– Autophagy-related protein [Medicago truncatula] gi|357475421|ref|XP_003607996.1|
Domains
11
Lj0g3v0313759.3
– Autophagy-related protein [Medicago truncatula] gi|357475421|ref|XP_003607996.1|
Domains
7
LotjaGi4g1v0073100.2
– Autophagy-related protein 2; TAIR: AT3G19190.2 autophagy 2; Swiss-Prot: sp|F8S296|ATG2_ARATH Autophagy-related protein 2; TrEMBL-Plants: tr|G7JLA6|G7JLA6_MEDTR Autophagy protein; Found in the gene: LotjaGi4g1v0073100
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 25.00