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IPR015898 is a G-protein gamma-like domain.
<p>This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended α-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS (regulators of G protein signaling) proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between β-propeller proteins and their partners [[cite:PUB00015235]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | G protein-coupled receptor signaling pathway | A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: guanine nucleotide-binding protein subunit gamma 2-like [Cicer arietinum] gi|502124605|ref|XP_004498598.1| | 7 | ||
| – | PREDICTED: guanine nucleotide-binding protein subunit gamma 2-like [Cicer arietinum] gi|502124605|ref|XP_004498598.1| | 6 | ||
| – | PREDICTED: guanine nucleotide-binding protein subunit gamma 3-like [Cicer arietinum] gi|502156506|ref|XP_004510508.1| | 5 | ||
| – | PREDICTED: guanine nucleotide-binding protein subunit gamma 3-like [Cicer arietinum] gi|502156506|ref|XP_004510508.1| | 5 | ||
| – | PREDICTED: guanine nucleotide-binding protein subunit gamma 2-like [Cicer arietinum] gi|502116415|ref|XP_004495420.1| | 7 | ||
| – | PREDICTED: guanine nucleotide-binding protein subunit gamma 3-like [Cicer arietinum] gi|502150534|ref|XP_004508000.1| | 7 | ||
| – | PREDICTED: guanine nucleotide-binding protein subunit gamma 3-like [Cicer arietinum] gi|502086047|ref|XP_004488092.1| | 8 | ||
| – | Guanine nucleotide-binding protein subunit gamma; TAIR: AT3G63420.3 Ggamma-subunit 1; Swiss-Prot: sp|A2X0N9|GG2_ORYSI Guanine nucleotide-binding protein subunit gamma 2; TrEMBL-Plants: tr|I3SQN8|I3SQN8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0797500 | 7 | ||
| – | Heterotrimeric G protein gamma subunit; TAIR: AT5G20635.1 guanine nucleotide-binding protein subunit gamma; Swiss-Prot: sp|Q6AWT8|GG3_ARATH Guanine nucleotide-binding protein subunit gamma 3; TrEMBL-Plants: tr|A0A0B2P152|A0A0B2P152_GLYSO Cation/calcium exchanger 4; Found in the gene: LotjaGi3g1v0413100 | 6 | ||
| – | Heterotrimeric G protein gamma subunit; TAIR: AT5G20635.1 guanine nucleotide-binding protein subunit gamma; Swiss-Prot: sp|Q6AWT8|GG3_ARATH Guanine nucleotide-binding protein subunit gamma 3; TrEMBL-Plants: tr|A0A0B2P152|A0A0B2P152_GLYSO Cation/calcium exchanger 4; Found in the gene: LotjaGi3g1v0413100 | 6 | ||
| – | Guanine nucleotide-binding protein subunit gamma; TAIR: AT5G20635.1 guanine nucleotide-binding protein subunit gamma; Swiss-Prot: sp|Q6AWT8|GG3_ARATH Guanine nucleotide-binding protein subunit gamma 3; TrEMBL-Plants: tr|I1MSA0|I1MSA0_SOYBN Dense and erect pancile 1; Found in the gene: LotjaGi4g1v0323500 | 7 | ||
| – | GTP binding protein gamma subunit; TAIR: AT3G63420.1 Ggamma-subunit 1; Swiss-Prot: sp|Q9FDX9|GG1_ARATH Guanine nucleotide-binding protein subunit gamma 1; TrEMBL-Plants: tr|G7ICP9|G7ICP9_MEDTR Guanine nucleotide-binding protein subunit gamma 2; Found in the gene: LotjaGi5g1v0173700 | 6 | ||
| – | Guanine nucleotide-binding protein subunit gamma; TAIR: AT3G22942.1 G-protein gamma subunit 2; Swiss-Prot: sp|Q93V47|GG2_ARATH Guanine nucleotide-binding protein subunit gamma 2; TrEMBL-Plants: tr|I3SXY5|I3SXY5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0193700 | 7 | ||
| – | GTP binding protein gamma subunit; TAIR: AT3G22942.1 G-protein gamma subunit 2; Swiss-Prot: sp|Q93V47|GG2_ARATH Guanine nucleotide-binding protein subunit gamma 2; TrEMBL-Plants: tr|I3T376|I3T376_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0194000 | 7 | ||
| – | Guanine nucleotide-binding protein subunit gamma; TAIR: AT5G20635.1 guanine nucleotide-binding protein subunit gamma; Swiss-Prot: sp|Q6AWT8|GG3_ARATH Guanine nucleotide-binding protein subunit gamma 3; TrEMBL-Plants: tr|K7LC96|K7LC96_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0224200_LC | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |