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IPR016067

Description

IPR016067 is a S-adenosylmethionine decarboxylase, core.

<p>S-adenosylmethionine decarboxylase (AdoMetDC) [[cite:PUB00006224]] catalyses the removal of the carboxylate group of S-adenosylmethionine to form S-adenosyl-5'-3-methylpropylamine which then acts as the n-propylamine group donor in the synthesis of the polyamines spermidine and spermine from putrescine.</p> <p>The catalytic mechanism of AdoMetDC involves a covalently-bound pyruvoyl group. This group is post-translationally generated by a self-catalyzed intramolecular proteolytic cleavage reaction between a glutamate and a serine. This cleavage generates two chains, beta (N-terminal) and alpha (C-terminal). The N-terminal serine residue of the alpha chain is then converted by non hydrolytic serinolysis into a pyruvoyl group.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Adenosylmethionine decarboxylase activity Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2).
Biological process Spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

Associated Lotus transcripts 16

Transcript Name Description Predicted domains Domain count
PREDICTED: S-adenosylmethionine decarboxylase proenzyme-like isoform X2 [Cicer arietinum] gi|502094794|ref|XP_004490299.1| 12
PREDICTED: S-adenosylmethionine decarboxylase proenzyme-like isoform X2 [Cicer arietinum] gi|502094794|ref|XP_004490299.1| 12
PREDICTED: S-adenosylmethionine decarboxylase proenzyme 1-like [Glycine max] gi|356557859|ref|XP_003547228.1| 11
PREDICTED: LOW QUALITY PROTEIN: S-adenosylmethionine decarboxylase proenzyme-like [Glycine max] gi|356568871|ref|XP_003552631.1| 12
PREDICTED: S-adenosylmethionine decarboxylase proenzyme 1-like [Glycine max] gi|356557859|ref|XP_003547228.1| 6
S-adenosylmethionine decarboxylase [Medicago falcata] gi|139478093|gb|ABO77440.1| 12
PREDICTED: S-adenosylmethionine decarboxylase proenzyme 1-like [Glycine max] gi|356557859|ref|XP_003547228.1| 7
7
PREDICTED: S-adenosylmethionine decarboxylase proenzyme 1-like [Glycine max] gi|356557859|ref|XP_003547228.1| 7
S-adenosylmethionine decarboxylase proenzyme; TAIR: AT3G02470.1 S-adenosylmethionine decarboxylase; Swiss-Prot: sp|Q96471|DCAM_IPONI S-adenosylmethionine decarboxylase proenzyme; TrEMBL-Plants: tr|A0A0R4J5V8|A0A0R4J5V8_SOYBN S-adenosylmethionine decarboxylase proenzyme; Found in the gene: LotjaGi1g1v0523700 12
S-adenosylmethionine decarboxylase proenzyme; TAIR: AT3G02470.1 S-adenosylmethionine decarboxylase; Swiss-Prot: sp|Q96471|DCAM_IPONI S-adenosylmethionine decarboxylase proenzyme; TrEMBL-Plants: tr|A0A0R4J5V8|A0A0R4J5V8_SOYBN S-adenosylmethionine decarboxylase proenzyme; Found in the gene: LotjaGi1g1v0523700 12
S-adenosylmethionine decarboxylase proenzyme; TAIR: AT3G25570.1 Adenosylmethionine decarboxylase family protein; Swiss-Prot: sp|Q9M4D8|DCAM_VICFA S-adenosylmethionine decarboxylase proenzyme; TrEMBL-Plants: tr|A0A072TH61|A0A072TH61_MEDTR S-adenosylmethionine decarboxylase proenzyme; Found in the gene: LotjaGi2g1v0286300 12
S-adenosylmethionine decarboxylase proenzyme; TAIR: AT3G25570.1 Adenosylmethionine decarboxylase family protein; Swiss-Prot: sp|Q9M4D8|DCAM_VICFA S-adenosylmethionine decarboxylase proenzyme; TrEMBL-Plants: tr|A0A072TH61|A0A072TH61_MEDTR S-adenosylmethionine decarboxylase proenzyme; Found in the gene: LotjaGi2g1v0286300 12
S-adenosylmethionine decarboxylase proenzyme; TAIR: AT3G25570.1 Adenosylmethionine decarboxylase family protein; Swiss-Prot: sp|Q9M4D8|DCAM_VICFA S-adenosylmethionine decarboxylase proenzyme; TrEMBL-Plants: tr|A0A072TTM8|A0A072TTM8_MEDTR S-adenosylmethionine decarboxylase proenzyme; Found in the gene: LotjaGi4g1v0153000 12
S-adenosylmethionine decarboxylase proenzyme; TAIR: AT5G18930.1 Adenosylmethionine decarboxylase family protein; Swiss-Prot: sp|Q3E9D5|DCAM4_ARATH S-adenosylmethionine decarboxylase proenzyme 4; TrEMBL-Plants: tr|I1MFB1|I1MFB1_SOYBN S-adenosylmethionine decarboxylase proenzyme; Found in the gene: LotjaGi6g1v0302300 12
S-adenosylmethionine decarboxylase proenzyme; TAIR: AT5G18930.1 Adenosylmethionine decarboxylase family protein; Swiss-Prot: sp|Q3E9D5|DCAM4_ARATH S-adenosylmethionine decarboxylase proenzyme 4; TrEMBL-Plants: tr|I1MFB1|I1MFB1_SOYBN S-adenosylmethionine decarboxylase proenzyme; Found in the gene: LotjaGi6g1v0302400 12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00535 TIGRFAM 1 6.25