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IPR016278

Source: InterPro

Description

IPR016278 is a Dual specificity protein phosphatase 12.

<p>Human YVH1, also known as dual specificity phosphatase 12 (DUSP12), is a cell survival phosphatase that prevents both thermal and oxidative stress-induced cell death. Furthermore, it associates with multiple ribonucleoprotein particles and may affect a variety of fundamental cellular processes [[cite:PUB00085007]]. The enzyme is known as dual specificity protein phosphatase MPK-4 in<i>Drosophila</i> [[cite:PUB00085099]]. Yeast YVH1, on the other hand, is required for a late maturation step in the 60S biogenesis pathway [[cite:PUB00085008]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006470
Biological process Protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
Subterm of
GO:0008138
Molecular function Protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0662200.1
– Dual specificity protein phosphatase, putative; TAIR: AT4G18593.1 dual specificity protein phosphatase-like protein; Swiss-Prot: sp|Q9UNI6|DUS12_HUMAN Dual specificity protein phosphatase 12; TrEMBL-Plants: tr|Q2HSZ6|Q2HSZ6_MEDTR Dual specificity phosphatase domain protein; Found in the gene: LotjaGi1g1v0662200
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd14520 CDD 1 100.00