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IPR020422

Description

IPR020422 is a Dual specificity protein phosphatase domain.

<p>Tyrosine specific protein phosphatases (PTPases) ([ec:3.1.3.48]) contain two conserved cysteines, the second one has been shown to be absolutely required for activity. This entry represents the PTPase domain that centre on the active site cysteine. A number of conserved residues in its immediate vicinity have also been shown to be important. This domain can be found in dual specificity phosphatases.</p> <p>Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases [[cite:PUB00056895], [cite:PUB00056896]]. They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. They are structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR [[cite:PUB00005456], [cite:PUB00081637], [cite:PUB00081644]]. They are characterized as VHR- [[cite:PUB00081649], [cite:PUB00005219]] or Cdc25-like [[cite:PUB00081645], [cite:PUB00081646]].</p> <p>In general, DUSPs are classified into the following subgroups [[cite:PUB00056893]]:</p> <ul> <li>Slingshot phosphatases</li> <li>Phosphatase of regenerating liver (PRL)</li> <li>Cdc14 phosphatases</li> <li>Phosphatase and tensin homologue deleted on chromosome 10 (PTEN)-like and myotubularin phosphatases</li> <li>Mitogen-activated protein kinase phosphatases (MKPs)</li> <li>Atypical DUSPs</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Biological process Protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
Molecular function Protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Associated Lotus transcripts 52

Transcript Name Description Predicted domains Domain count
PREDICTED: mRNA-capping enzyme-like [Glycine max] gi|356568041|ref|XP_003552222.1| 29
PREDICTED: laforin-like [Glycine max] gi|356516265|ref|XP_003526816.1| 13
PREDICTED: dual specificity protein phosphatase PHS1-like [Cicer arietinum] gi|502133383|ref|XP_004501744.1| 21
PREDICTED: protein-tyrosine-phosphatase MKP1-like [Cicer arietinum] gi|502102464|ref|XP_004492084.1| 20
PREDICTED: phosphoglucan phosphatase LSF1, chloroplastic-like [Cicer arietinum] gi|502170387|ref|XP_004514819.1| 19
PREDICTED: dual specificity protein phosphatase 12-like isoform X2 [Cicer arietinum] gi|502108122|ref|XP_004493392.1| 16
PREDICTED: mRNA-capping enzyme-like [Glycine max] gi|356570562|ref|XP_003553454.1| 26
PREDICTED: protein-tyrosine-phosphatase IBR5-like [Glycine max] gi|356501245|ref|XP_003519436.1| 16
PREDICTED: mRNA-capping enzyme-like [Glycine max] gi|356504293|ref|XP_003520931.1| 22
PREDICTED: mRNA-capping enzyme-like [Glycine max] gi|356496154|ref|XP_003516935.1| 29
PREDICTED: protein-tyrosine phosphatase mitochondrial 1-like protein-like [Glycine max] gi|356510670|ref|XP_003524059.1| 15
PREDICTED: dual specificity protein phosphatase 1-like isoform X1 [Cicer arietinum] gi|502151309|ref|XP_004508377.1| 14
PREDICTED: dual specificity protein phosphatase 1-like isoform X2 [Cicer arietinum] gi|502151311|ref|XP_004508378.1| 13
PREDICTED: dual specificity protein phosphatase PHS1-like [Cicer arietinum] gi|502139515|ref|XP_004503799.1| 22
PREDICTED: protein-tyrosine phosphatase mitochondrial 1-like [Glycine max] gi|356523809|ref|XP_003530527.1| 15
PREDICTED: phosphoglucan phosphatase DSP4, chloroplastic-like [Cicer arietinum] gi|502118212|ref|XP_004496155.1| 18
Phosphotyrosine protein phosphatases superfamily protein [Theobroma cacao] gi|508721723|gb|EOY13620.1| 16
PREDICTED: protein-tyrosine-phosphatase MKP1-like isoform X1 [Cicer arietinum] gi|502135593|ref|XP_004502386.1| 20
PREDICTED: protein-tyrosine-phosphatase MKP1-like isoform X2 [Cicer arietinum] gi|502135596|ref|XP_004502387.1| 20
Dual specificity protein phosphatase, putative; TAIR: AT2G04550.1 indole-3-butyric acid response 5; Swiss-Prot: sp|Q84JU4|IBR5_ARATH Protein-tyrosine-phosphatase IBR5; TrEMBL-Plants: tr|I1JIH0|I1JIH0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0068800 16
Dual specificity protein phosphatase, putative; TAIR: AT3G10940.1 dual specificity protein phosphatase (DsPTP1) family protein; Swiss-Prot: sp|Q9SRK5|LSF2_ARATH Phosphoglucan phosphatase LSF2, chloroplastic; TrEMBL-Plants: tr|I3SHM7|I3SHM7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0309000 13
Dual specificity phosphatase family protein; TAIR: AT5G23720.1 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|A0A0S3RFM3|A0A0S3RFM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0334000 21
Dual specificity phosphatase family protein; TAIR: AT5G23720.3 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|A0A151R609|A0A151R609_CAJCA Dual specificity protein phosphatase 3; Found in the gene: LotjaGi1g1v0334000 14
Dual specificity phosphatase; TAIR: AT3G55270.1 mitogen-activated protein kinase phosphatase 1; Swiss-Prot: sp|Q9C5S1|MKP1_ARATH Protein-tyrosine-phosphatase MKP1; TrEMBL-Plants: tr|A0A0L9U245|A0A0L9U245_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0533600 19
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|K7MTE7|K7MTE7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0572100 30
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|K7MTE7|K7MTE7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0572100 29
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|A0A0R0FB81|A0A0R0FB81_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0572100 29
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|K7MTE7|K7MTE7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0572100 29
Phosphoglucan phosphatase LSF1; TAIR: AT3G01510.1 like SEX4 1; Swiss-Prot: sp|F4J117|LSF1_ARATH Phosphoglucan phosphatase LSF1, chloroplastic; TrEMBL-Plants: tr|K7MWV8|K7MWV8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0607500 22
Dual specificity protein phosphatase, putative; TAIR: AT4G18593.1 dual specificity protein phosphatase-like protein; Swiss-Prot: sp|Q9UNI6|DUS12_HUMAN Dual specificity protein phosphatase 12; TrEMBL-Plants: tr|Q2HSZ6|Q2HSZ6_MEDTR Dual specificity phosphatase domain protein; Found in the gene: LotjaGi1g1v0662200 15
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|A0A0B2SM84|A0A0B2SM84_GLYSO mRNA-capping enzyme; Found in the gene: LotjaGi1g1v0728900 27
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|K7KDH1|K7KDH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0215700 23
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|K7K355|K7K355_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0215700 30
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|A0A151RAA8|A0A151RAA8_CAJCA mRNA-capping enzyme; Found in the gene: LotjaGi3g1v0215700 29
MRNA-capping enzyme; TAIR: AT3G09100.2 mRNA capping enzyme family protein; Swiss-Prot: sp|O55236|MCE1_MOUSE mRNA-capping enzyme; TrEMBL-Plants: tr|K7K355|K7K355_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0215700 30
Dual specificity protein phosphatase; TAIR: AT2G35680.1 Phosphotyrosine protein phosphatases superfamily protein; Swiss-Prot: sp|Q9ZQP1|DSP8_ARATH Putative dual specificity protein phosphatase DSP8; TrEMBL-Plants: tr|I1K0T6|I1K0T6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0200000 15
Dual specificity protein phosphatase; TAIR: AT3G23610.1 dual specificity protein phosphatase 1; Swiss-Prot: sp|Q9ZR37|DUS1_ARATH Dual specificity protein phosphatase 1; TrEMBL-Plants: tr|A0A072V237|A0A072V237_MEDTR Dual specificity protein phosphatase; Found in the gene: LotjaGi4g1v0352400 13
Dual specificity protein phosphatase, putative; TAIR: AT3G55270.1 mitogen-activated protein kinase phosphatase 1; Swiss-Prot: sp|Q9C5S1|MKP1_ARATH Protein-tyrosine-phosphatase MKP1; TrEMBL-Plants: tr|A0A1J7GIS4|A0A1J7GIS4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0392500 19
Dual specificity phosphatase family protein; TAIR: AT5G23720.1 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|A0A1J7IUU8|A0A1J7IUU8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421000 14
Dual specificity phosphatase family protein; TAIR: AT5G23720.1 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|A0A072TU75|A0A072TU75_MEDTR Dual specificity phosphatase family protein; Found in the gene: LotjaGi4g1v0421000 22
Dual specificity phosphatase family protein; TAIR: AT5G23720.1 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|A0A0B2Q765|A0A0B2Q765_GLYSO Dual specificity protein phosphatase 1; Found in the gene: LotjaGi4g1v0421000 21
Dual specificity phosphatase family protein; TAIR: AT5G23720.1 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|K7KS75|K7KS75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421000 22
Dual specificity phosphatase family protein; TAIR: AT5G23720.3 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|A0A0B2Q765|A0A0B2Q765_GLYSO Dual specificity protein phosphatase 1; Found in the gene: LotjaGi4g1v0421000 21
Dual specificity phosphatase family protein; TAIR: AT5G23720.1 dual specificity protein phosphatase family protein; Swiss-Prot: sp|Q75QN6|DPHS1_ARATH Dual specificity protein phosphatase PHS1; TrEMBL-Plants: tr|A0A1J7IUU8|A0A1J7IUU8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421000 14
Dual specificity phosphatase; TAIR: AT2G35680.1 Phosphotyrosine protein phosphatases superfamily protein; Swiss-Prot: sp|Q9ZQP1|DSP8_ARATH Putative dual specificity protein phosphatase DSP8; TrEMBL-Plants: tr|I1KPV3|I1KPV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0443600 15
Dual specificity phosphatase; TAIR: AT2G35680.1 Phosphotyrosine protein phosphatases superfamily protein; Swiss-Prot: sp|Q9ZQP1|DSP8_ARATH Putative dual specificity protein phosphatase DSP8; TrEMBL-Plants: tr|G7L7D1|G7L7D1_MEDTR Dual specificity phosphatase domain protein; Found in the gene: LotjaGi4g1v0443600 15
Dual specificity phosphatase; TAIR: AT2G35680.1 Phosphotyrosine protein phosphatases superfamily protein; Swiss-Prot: sp|Q9ZQP1|DSP8_ARATH Putative dual specificity protein phosphatase DSP8; TrEMBL-Plants: tr|I1KPV3|I1KPV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0443600 15
Dual specificity phosphatase; TAIR: AT3G52180.1 dual specificity protein phosphatase (DsPTP1) family protein; Swiss-Prot: sp|G4LTX4|DSP4_CASSA Phosphoglucan phosphatase DSP4, amyloplastic; TrEMBL-Plants: tr|I3SIE2|I3SIE2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0264500 21
Dual specificity protein phosphatase family protein; TAIR: AT5G56610.1 Phosphotyrosine protein phosphatases superfamily protein; Swiss-Prot: sp|P76093|YNBD_ECOLI Uncharacterized protein YnbD; TrEMBL-Plants: tr|I3T491|I3T491_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0344700 16
Dual specificity protein phosphatase, putative; TAIR: AT3G55270.1 mitogen-activated protein kinase phosphatase 1; Swiss-Prot: sp|Q9C5S1|MKP1_ARATH Protein-tyrosine-phosphatase MKP1; TrEMBL-Plants: tr|V7D1Y7|V7D1Y7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0095400 19
Dual specificity protein phosphatase, putative; TAIR: AT3G55270.1 mitogen-activated protein kinase phosphatase 1; Swiss-Prot: sp|Q9C5S1|MKP1_ARATH Protein-tyrosine-phosphatase MKP1; TrEMBL-Plants: tr|V7D1Y7|V7D1Y7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0095400 19
Dual specificity protein phosphatase, putative; TAIR: AT3G55270.1 mitogen-activated protein kinase phosphatase 1; Swiss-Prot: sp|Q9C5S1|MKP1_ARATH Protein-tyrosine-phosphatase MKP1; TrEMBL-Plants: tr|V7D1Y7|V7D1Y7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0095400 19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 1.92