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IPR016454 is a Cysteine desulfurase.
<p>This group represents a cysteine desulfurase, NifS type. NifS-like proteins are homodimeric and belong to the alpha-family of pyridoxal-5'-phoshate dependent enzymes [[cite:PUB00024498]] which catalyse the reaction:<reaction>L-cysteine + (enzyme)-cysteine = L-alanine + (enzyme)-S-sulphanylcysteine</reaction></p> <p>Cysteine desulfurase proteins play a central role in the delivery of sulphur to a variety of metabolic pathways [[cite:PUB00029701]]. It is involved in the biosynthesis of iron-sulphur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) [[cite:PUB00028013]]. They are present in all organisms (except viruses). In eukaryotes these enzymes occur in mitochondria since this is the primary site for Fe-S cluster assembly [[cite:PUB00043342]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cysteine desulfurase 1, mitochondrial-like isoform 1 [Glycine max] gi|356497029|ref|XP_003517367.1| | 15 | ||
| – | Cysteine desulfurase IscS; TAIR: AT5G65720.1 nitrogen fixation S (NIFS)-like 1; Swiss-Prot: sp|O49543|MNIF1_ARATH Cysteine desulfurase, mitochondrial; TrEMBL-Plants: tr|A0A1J7FXI5|A0A1J7FXI5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0412800 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR02006 | TIGRFAM | 1 | 50.00 |