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IPR010240 is a Cysteine desulfurase IscS.
<p>This entry represents cysteine deusulfurase (IscS), one of several cysteine desulfurases from a larger protein family designated (misleadingly, in this case) class V aminotransferases. IscS is one of at least 6 enzymes characteristic of the IscSUA-hscAB-fsx system of iron-sulphur cluster assembly [[cite:PUB00021001], [cite:PUB00043028], [cite:PUB00095247]]. In M. tuberculosis this enzyme is associated with oxidative stress defence [[cite:PUB00095247]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. | ||
| Molecular function | Cysteine desulfurase activity | Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. | ||
| Biological process | [2Fe-2S] cluster assembly | The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cysteine desulfurase 1, mitochondrial-like isoform 1 [Glycine max] gi|356497029|ref|XP_003517367.1| | 15 | ||
| – | Cysteine desulfurase IscS; TAIR: AT5G65720.1 nitrogen fixation S (NIFS)-like 1; Swiss-Prot: sp|O49543|MNIF1_ARATH Cysteine desulfurase, mitochondrial; TrEMBL-Plants: tr|A0A1J7FXI5|A0A1J7FXI5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0412800 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR02006 | TIGRFAM | 1 | 50.00 |