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IPR017380 is a Histone acetyltransferase type B, catalytic subunit.
<p>This entry represents the catalytic subunit of histone acetyltransferase type B ([ec:2.3.1.48]) (also known as HAT1), which is the catalytic component of the histone acetylase B (HAT-B) complex [[cite:PUB00044716], [cite:PUB00044717], [cite:PUB00044718]]. The HAT-B complex is composed of at least HAT1 and HAT2. In the cytoplasm, this complex binds to the histone H4 tail. In the nucleus, the HAT-B complex has an additional component, the histone H3/H4 chaperone HIF1.</p> <p>This enzyme acetylates soluble but not nucleosomal H4 at Lys-12, which is required for telomeric silencing. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. It is involved in DNA double-strand break repair [[cite:PUB00063095]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | Chromatin silencing at telomere | Repression of transcription of telomeric DNA by altering the structure of chromatin. | ||
| Biological process | Histone acetylation | The modification of a histone by the addition of an acetyl group. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: histone acetyltransferase type B catalytic subunit-like [Glycine max] gi|356551642|ref|XP_003544183.1| | 11 | ||
| – | Histone acetyltransferase; TAIR: AT5G56740.1 histone acetyltransferase of the GNAT family 2; Swiss-Prot: sp|Q9FJT8|HATB_ARATH Histone acetyltransferase type B catalytic subunit; TrEMBL-Plants: tr|I1M828|I1M828_SOYBN Histone acetyltransferase; Found in the gene: LotjaGi1g1v0086700 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04301 | CDD | 1 | 50.00 |