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IPR017861 is a Kae1/TsaD family.
<p>The first characterised member of the Kae1/TsaD family was annotated as Gcp for O-sialoglycoprotein endopeptidase [[cite:PUB00002152]], but this activity could not be confirmed [[cite:PUB00047751]]. Later, its homologue, Kae1 from Pyrococcus abyssi, has been shown to have DNA-binding properties and apurinic-endonuclease activity [[cite:PUB00047751]]. Members of this family have since been studied in yeast, archaea and bacteria resulting in sometimes conflicting data, several proposed functions and annotations but no definitive characterisation. For instance, some members have been linked to DNA maintenance in bacteria and mitochondria [[cite:PUB00059916]] and transcription regulation and telomere homeostasis in eukaryotes [[cite:PUB00035445], [cite:PUB00035406]], but their function remained unclear. Recent research indicates that this family is involved in the biosynthesis of N6-threonylcarbamoyl adenosine, a universal modification found at position 37 of tRNAs that read codons beginning with adenine [[cite:PUB00059911], [cite:PUB00101388]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep-like [Glycine max] gi|356573183|ref|XP_003554743.1| | 11 | ||
| – | PREDICTED: probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep-like [Glycine max] gi|356573183|ref|XP_003554743.1| | 10 | ||
| – | PREDICTED: probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep-like [Glycine max] gi|356573183|ref|XP_003554743.1| | 10 | ||
| – | PREDICTED: probable tRNA threonylcarbamoyladenosine biosynthesis protein osgepl1-like [Glycine max] gi|356506230|ref|XP_003521890.1| | 11 | ||
| – | TRNA N6-adenosine threonylcarbamoyltransferase; TAIR: AT4G22720.1 Actin-like ATPase superfamily protein; Swiss-Prot: sp|Q9WVS2|OSGEP_RAT Probable tRNA N6-adenosine threonylcarbamoyltransferase; TrEMBL-Plants: tr|I1NCH1|I1NCH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0788800 | 13 | ||
| – | TRNA N6-adenosine threonylcarbamoyltransferase; TAIR: AT4G22720.1 Actin-like ATPase superfamily protein; Swiss-Prot: sp|Q9WVS2|OSGEP_RAT Probable tRNA N6-adenosine threonylcarbamoyltransferase; TrEMBL-Plants: tr|I1NCH1|I1NCH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0788800 | 13 | ||
| – | TRNA N6-adenosine threonylcarbamoyltransferase; TAIR: AT4G22720.1 Actin-like ATPase superfamily protein; Swiss-Prot: sp|Q9WVS2|OSGEP_RAT Probable tRNA N6-adenosine threonylcarbamoyltransferase; TrEMBL-Plants: tr|I1NCH1|I1NCH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0788800 | 11 | ||
| – | TRNA N6-adenosine threonylcarbamoyltransferase; TAIR: AT4G22720.1 Actin-like ATPase superfamily protein; Swiss-Prot: sp|Q9WVS2|OSGEP_RAT Probable tRNA N6-adenosine threonylcarbamoyltransferase; TrEMBL-Plants: tr|I1NCH1|I1NCH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0788800 | 13 | ||
| – | TRNA N6-adenosine threonylcarbamoyltransferase; TAIR: AT2G45270.1 glycoprotease 1; Swiss-Prot: sp|O22145|OSGP2_ARATH Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A0S3SYJ9|A0A0S3SYJ9_PHAAN Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Found in the gene: LotjaGi3g1v0435500 | 12 | ||
| – | TRNA N6-adenosine threonylcarbamoyltransferase; TAIR: AT2G45270.1 glycoprotease 1; Swiss-Prot: sp|O22145|OSGP2_ARATH Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A0S3SYJ9|A0A0S3SYJ9_PHAAN Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Found in the gene: LotjaGi3g1v0435500 | 19 | ||
| – | TRNA N6-adenosine threonylcarbamoyltransferase; TAIR: AT2G45270.1 glycoprotease 1; Swiss-Prot: sp|O22145|OSGP2_ARATH Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A0S3SYJ9|A0A0S3SYJ9_PHAAN Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Found in the gene: LotjaGi3g1v0435500 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR03723 | TIGRFAM | 1 | 9.09 |