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IPR017870

Description

IPR017870 is a FeS cluster insertion, C-terminal, conserved site.

<p>This entry represents a conserved site at the C-terminal in ATAP proteins during FeS cluster formation and iron-binding proteins.</p> <p>A-type assembly protein (ATAP) is a conserved and essential member of the ISC, SUF, and NIF systems and plays an indispensable role in the FeS cluster assembly and the transfer process. The ATAP family consists of several subfamilies:</p> <ul><li>Prokaryotic ISC system: IscA</li> <li>Eukaryotic ISC system: ISCA1, ISCA2</li><li>SUF system: SufA</li><li>NIF system: HesB (IscAnif)</li> <li>Additional proteins: ErpA, cpIscA</li></ul> <p>ATAPs are characterised by a conserved motif, Cys-Xn-Cys-X-Cys, by which ATAPs can bind transiently to Fe-S clusters, presumably using the three Cys residues in this motif, and transfer the FeS cluster to apoproteins [[cite:PUB00160405], [cite:PUB00160406]]. ErpA may interact with ISC and SUF. It binds to Fe-S clusters and transfers them to apo-IspG, which is involved in quinone biosynthesis among many other cell components [[cite:PUB00058194]]. It is essential for bacterial growth under aerobic conditions. cpIscA is a SufA-like ATAP that was transferred from cyanobacteria to plants through endosymbiosis events and now is only harboured by plant plastids [[cite:PUB00160405]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
PREDICTED: iron-sulfur assembly protein IscA-like 1, mitochondrial-like [Cicer arietinum] gi|502111353|ref|XP_004494031.1| 7
PREDICTED: iron-sulfur assembly protein IscA, chloroplastic-like [Cicer arietinum] gi|502140001|ref|XP_004504011.1| 11
PREDICTED: iron-sulfur assembly protein IscA, chloroplastic-like [Cicer arietinum] gi|502140001|ref|XP_004504011.1| 11
Iron-sulfur cluster insertion protein erpA; TAIR: AT2G16710.1 Iron-sulfur cluster biosynthesis family protein; Swiss-Prot: sp|Q8LBM4|ISAM1_ARATH Iron-sulfur assembly protein IscA-like 1, mitochondrial; TrEMBL-Plants: tr|I1JQ14|I1JQ14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0676300 11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00049 TIGRFAM 1 25.00