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IPR035903 is a HesB-like domain superfamily.
<p>The HesB family is found in species as divergent as Homo sapiens (Human) and Haemophilus influenzae, suggesting that these proteins are involved in basic cellular functions [[cite:PUB00003442]].</p> <p>A-type assembly protein (ATAP) is a conserved and essential member of the ISC, SUF, and NIF systems and plays an indispensable role in the FeS cluster assembly and the transfer process. The ATAP family consists of several subfamilies:</p> <ul><li>Prokaryotic ISC system: IscA</li> <li>Eukaryotic ISC system: ISCA1, ISCA2</li><li>SUF system: SufA</li><li>NIF system: HesB (IscAnif)</li> <li>Additional proteins: ErpA, cpIscA</li></ul> <p>ATAPs are characterised by a conserved motif, Cys-Xn-Cys-X-Cys, by which ATAPs can bind transiently to Fe-S clusters, presumably using the three Cys residues in this motif, and transfer the FeS cluster to apoproteins [[cite:PUB00160405], [cite:PUB00160406]]. ErpA may interact with ISC and SUF. It binds to Fe-S clusters and transfers them to apo-IspG, which is involved in quinone biosynthesis among many other cell components [[cite:PUB00058194]]. It is essential for bacterial growth under aerobic conditions. cpIscA is a SufA-like ATAP that was transferred from cyanobacteria to plants through endosymbiosis events and now is only harboured by plant plastids [[cite:PUB00160405]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Iron-sulfur cluster insertion protein ErpA; TAIR: AT5G03905.1 Iron-sulfur cluster biosynthesis family protein; Swiss-Prot: sp|Q8LCY2|ISAM2_ARATH Iron-sulfur assembly protein IscA-like 2, mitochondrial; TrEMBL-Plants: tr|I3SBC4|I3SBC4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0675900 | 9 | ||
| – | Iron-sulfur cluster insertion protein erpA; TAIR: AT2G16710.1 Iron-sulfur cluster biosynthesis family protein; Swiss-Prot: sp|Q8LBM4|ISAM1_ARATH Iron-sulfur assembly protein IscA-like 1, mitochondrial; TrEMBL-Plants: tr|I1JQ14|I1JQ14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0676300 | 11 | ||
| – | Iron-sulfur cluster insertion protein ErpA; TAIR: AT5G03905.1 Iron-sulfur cluster biosynthesis family protein; Swiss-Prot: sp|Q8LCY2|ISAM2_ARATH Iron-sulfur assembly protein IscA-like 2, mitochondrial; TrEMBL-Plants: tr|I3SWV2|I3SWV2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0741100 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00049 | TIGRFAM | 1 | 33.33 |