Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR016092 is a FeS cluster insertion protein.
<p>Proteins in this entry include HesB, IscA, SufA and ErpA, and appear to be scaffold proteins upon which 2Fe-2S clusters are assembled and subsequently transferred to acceptor proteins.</p> <p>Several multiprotein complexes, referred to as ISC, SUF, and NIF, are known to be necessary for building and inserting Fe-S clusters into cellular targets [[cite:PUB00058196]]. The HesB proteins are associated with the nif gene cluster. The Escherichia coli SufA protein is associated with SufS, a NifS homologue, and SufD which are involved in the FeS cluster assembly of the FhnF protein [[cite:PUB00010345]]. The Azotobacter protein IscA (homologues of which are also found in E. coli) is associated which IscS, another NifS homologue, and IscU, a NifU homologue, as well as other factors consistent with a role in FeS cluster chemistry [[cite:PUB00017349]]. ErpA is required, together with IscA, for the delivery of iron-sulphur clusters to the hydrogen-oxidizing [NiFe]-hydrogenases in Escherichia coli [[cite:PUB00058194], [cite:PUB00058195]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. | ||
| Molecular function | Iron-sulfur cluster binding | Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. | ||
| Biological process | Protein maturation by iron-sulfur cluster transfer | The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Iron-sulfur assembly protein IscA-like protein [Medicago truncatula] gi|357511065|ref|XP_003625821.1| | 9 | ||
| – | PREDICTED: iron-sulfur assembly protein IscA-like 2, mitochondrial-like isoform X1 [Cicer arietinum] gi|502111834|ref|XP_004494179.1| | 8 | ||
| – | PREDICTED: iron-sulfur assembly protein IscA, chloroplastic-like [Cicer arietinum] gi|502140001|ref|XP_004504011.1| | 11 | ||
| – | PREDICTED: iron-sulfur assembly protein IscA, chloroplastic-like [Cicer arietinum] gi|502140001|ref|XP_004504011.1| | 11 | ||
| – | Iron-sulfur cluster insertion protein ErpA; TAIR: AT5G03905.1 Iron-sulfur cluster biosynthesis family protein; Swiss-Prot: sp|Q8LCY2|ISAM2_ARATH Iron-sulfur assembly protein IscA-like 2, mitochondrial; TrEMBL-Plants: tr|I3SBC4|I3SBC4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0675900 | 9 | ||
| – | Iron-sulfur cluster insertion protein erpA; TAIR: AT2G16710.1 Iron-sulfur cluster biosynthesis family protein; Swiss-Prot: sp|Q8LBM4|ISAM1_ARATH Iron-sulfur assembly protein IscA-like 1, mitochondrial; TrEMBL-Plants: tr|I1JQ14|I1JQ14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0676300 | 11 | ||
| – | Iron-sulfur cluster insertion protein ErpA; TAIR: AT5G03905.1 Iron-sulfur cluster biosynthesis family protein; Swiss-Prot: sp|Q8LCY2|ISAM2_ARATH Iron-sulfur assembly protein IscA-like 2, mitochondrial; TrEMBL-Plants: tr|I3SWV2|I3SWV2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0741100 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00049 | TIGRFAM | 1 | 14.29 |