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IPR018967 is a Iron-binding zinc finger, CDGSH type.
<p>This entry represents iron-sulphur domain containing proteins that have a CDGSH sequence motif (although the Ser residue can also be an Ala or Thr), and is found in proteins from a wide range of organisms with the exception of fungi. The CDGSH-type domain binds a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family [[cite:PUB00035840]].</p> <p>CDGSH-type domains are found in mitoNEET, an iron-containing integral protein of the outer mitochondrian membrane (OMM). MitoNEET forms a dimeric structure with a NEET fold, and contains two domains: a β-cap region and a cluster-binding domain that coordinated two acid-labile 2Fe-2S clusters (one bound to each protomer) [[cite:PUB00042908]]. The CDGSH iron-sulphur domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, ([interpro:IPR019610]) [[cite:PUB00044559], [cite:PUB00042908]]. The whole protein regulates oxidative capacity and may function in electron transfer, for instance in redox reactions with metabolic intermediates, cofactors and/or proteins localized at the OMM.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. | ||
| Molecular function | 2 iron, 2 sulfur cluster binding | Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: CDGSH iron-sulfur domain-containing protein 2-like [Glycine max] gi|356559911|ref|XP_003548239.1| | 4 | ||
| – | CDGSH iron-sulfur domain-containing protein 2; TAIR: AT5G51720.1 2 iron, 2 sulfur cluster binding protein; Swiss-Prot: sp|Q9FLI7|NEET_ARATH CDGSH iron-sulfur domain-containing protein NEET; TrEMBL-Plants: tr|I3T106|I3T106_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0158700 | 7 | ||
| – | CDGSH iron-sulfur domain-containing protein 2; TAIR: AT5G51720.1 2 iron, 2 sulfur cluster binding protein; Swiss-Prot: sp|Q9FLI7|NEET_ARATH CDGSH iron-sulfur domain-containing protein NEET; TrEMBL-Plants: tr|I3T106|I3T106_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0158700 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SM00704 | SMART | 1 | 33.33 |