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IPR019134 is a Splicing factor Cactin, C-terminal.
<p>This entry represents the C-terminal β-sandwich domain of the splicing factor cactin [[cite:PUB00101922]], which is necessary for the association of cactin with the IkappaB protein cactus, as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival [[cite:PUB00101936]]. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development and in the establishment of dorsal-ventral polarity in the early embryo [[cite:PUB00044178]]. Members of this entry play a role in pre-mRNA splicing by facilitating excision of a subset of introns [[cite:PUB00101935]].</p> <p>Most members of the family also have the conserved mid region of cactin ([interpro:IPR018816]) further upstream.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cactin-like [Cicer arietinum] gi|502111606|ref|XP_004494109.1| | 9 | ||
| – | Cactin; TAIR: AT1G03910.1 cactus-binding carboxy-terminal, cactin; Swiss-Prot: sp|F4I2J8|CATIN_ARATH Cactin; TrEMBL-Plants: tr|I1NAG1|I1NAG1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0682800 | 9 | ||
| – | Cactin; TAIR: AT1G03910.1 cactus-binding carboxy-terminal, cactin; Swiss-Prot: sp|F4I2J8|CATIN_ARATH Cactin; TrEMBL-Plants: tr|I1JPU2|I1JPU2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0682800 | 8 | ||
| – | Cactin; TAIR: AT1G03910.1 cactus-binding carboxy-terminal, cactin; Swiss-Prot: sp|F4I2J8|CATIN_ARATH Cactin; TrEMBL-Plants: tr|A0A151TV86|A0A151TV86_CAJCA Uncharacterized protein C19orf29 isogeny; Found in the gene: LotjaGi2g1v0065200 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SM01050 | SMART | 1 | 25.00 |