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IPR019190 is a Exonuclease V.
<p>In Saccharomyces cerevisiae (Baker's yeast), Exo5 is a single strand DNA specific 5'-exonuclease, which is involved in mitochondrial DNA replication and recombination. It has the capacity to slide across 5' double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively [[cite:PUB00062398]]. It degrades single-stranded, but not double-stranded, DNA from the 5'-end, and the products are dinucleotides, except the 3'-terminal tri- and tetranucleotides, which are not degraded. The initial hydrolytic cut of exonuclease V on the dephosphorylated substrate produces a mixture of dinucleoside monophosphates and trinucleoside diphosphates [[cite:PUB00066720]]. Exo5 is specific for single-stranded DNA and does not hydrolyze RNA [[cite:PUB00062398]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Single-stranded DNA 5'-3' exodeoxyribonuclease activity | Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable exonuclease V-like [Glycine max] gi|356539114|ref|XP_003538045.1| | 4 | ||
| – | PREDICTED: probable exonuclease V-like [Glycine max] gi|356539114|ref|XP_003538045.1| | 5 | ||
| – | PREDICTED: probable exonuclease V-like [Glycine max] gi|356539114|ref|XP_003538045.1| | 4 | ||
| – | PREDICTED: exonuclease V, chloroplastic-like [Cicer arietinum] gi|502120509|ref|XP_004496985.1| | 3 | ||
| – | 3 | |||
| – | Exonuclease V-like protein; TAIR: AT5G60370.1 exonuclease V-like protein; Swiss-Prot: sp|Q9FKK6|EXO5_ARATH Exonuclease V, chloroplastic; TrEMBL-Plants: tr|I1LKD2|I1LKD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0363200 | 5 | ||
| – | Exonuclease V-like protein; TAIR: AT5G60370.1 exonuclease V-like protein; Swiss-Prot: sp|Q9FKK6|EXO5_ARATH Exonuclease V, chloroplastic; TrEMBL-Plants: tr|V7AF84|V7AF84_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0365000 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |