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IPR020613 is a Thiolase, conserved site.
<p>Two different types of thiolase [[cite:PUB00001113], [cite:PUB00002552], [cite:PUB00003423]] are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase ([ec:2.3.1.9]) and 3-ketoacyl-CoA thiolase ([ec:2.3.1.16]). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or steroid biogenesis.</p> <p>In eukaryotes, there are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes.</p> <p>There are two conserved cysteine residues important for thiolase activity. The first located in the N-terminal section of the enzymes is involved in the formation of an acyl-enzyme intermediate; the second located at the C-terminal extremity is the active site base involved in deprotonation in the condensation reaction [[cite:PUB00052320]].</p> <p>Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). The former is found in the cytoplasm or the mitochondria and is involved in lipid transport; the latter is found in peroxisomes. The C-terminal part of SCP-x is identical to SCP-2 while the N-terminal portion is evolutionary related to thiolases [[cite:PUB00001113]].</p> <p>The signature pattern for this entry is a conserved sequence located towards the C-terminal end.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Transferase activity, transferring acyl groups other than amino-acyl groups | Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 3-ketoacyl-CoA thiolase 2, peroxisomal-like [Cicer arietinum] gi|502146749|ref|XP_004506590.1| | 22 | ||
| – | PREDICTED: acetyl-CoA acetyltransferase, cytosolic 1-like [Glycine max] gi|356554441|ref|XP_003545555.1| | 17 | ||
| – | Acetyl-CoA C-acetyltransferase [Hevea brasiliensis] gi|164604960|dbj|BAF98276.1| | 15 | ||
| – | Acetyl-CoA C-acetyltransferase [Hevea brasiliensis] gi|164604960|dbj|BAF98276.1| | 15 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT5G48230.2 acetoacetyl-CoA thiolase 2; Swiss-Prot: sp|Q8S4Y1|THIC1_ARATH Acetyl-CoA acetyltransferase, cytosolic 1; TrEMBL-Plants: tr|A0A0R0GDY6|A0A0R0GDY6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0005300 | 17 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT5G48230.2 acetoacetyl-CoA thiolase 2; Swiss-Prot: sp|Q8S4Y1|THIC1_ARATH Acetyl-CoA acetyltransferase, cytosolic 1; TrEMBL-Plants: tr|A0A0R0GDY6|A0A0R0GDY6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0005300 | 17 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT5G48230.1 acetoacetyl-CoA thiolase 2; Swiss-Prot: sp|Q8S4Y1|THIC1_ARATH Acetyl-CoA acetyltransferase, cytosolic 1; TrEMBL-Plants: tr|M5WS77|M5WS77_PRUPE Uncharacterized protein; Found in the gene: LotjaGi1g1v0005300 | 17 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT2G33150.1 peroxisomal 3-ketoacyl-CoA thiolase 3; Swiss-Prot: sp|Q56WD9|THIK2_ARATH 3-ketoacyl-CoA thiolase 2, peroxisomal; TrEMBL-Plants: tr|A0A151TF80|A0A151TF80_CAJCA 3-ketoacyl-CoA thiolase 2, peroxisomal; Found in the gene: LotjaGi3g1v0232400 | 23 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT2G33150.1 peroxisomal 3-ketoacyl-CoA thiolase 3; Swiss-Prot: sp|Q56WD9|THIK2_ARATH 3-ketoacyl-CoA thiolase 2, peroxisomal; TrEMBL-Plants: tr|A0A151TF80|A0A151TF80_CAJCA 3-ketoacyl-CoA thiolase 2, peroxisomal; Found in the gene: LotjaGi3g1v0232400 | 20 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT5G47720.2 Thiolase family protein; Swiss-Prot: sp|Q9FIK7|THIC2_ARATH Probable acetyl-CoA acetyltransferase, cytosolic 2; TrEMBL-Plants: tr|G7ZZU7|G7ZZU7_MEDTR Peroxisomal acetoacetyl-coenzyme A thiolase; Found in the gene: LotjaGi4g1v0005700 | 17 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT5G47720.2 Thiolase family protein; Swiss-Prot: sp|Q9FIK7|THIC2_ARATH Probable acetyl-CoA acetyltransferase, cytosolic 2; TrEMBL-Plants: tr|G7ZZU7|G7ZZU7_MEDTR Peroxisomal acetoacetyl-coenzyme A thiolase; Found in the gene: LotjaGi4g1v0005700 | 22 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT2G33150.1 peroxisomal 3-ketoacyl-CoA thiolase 3; Swiss-Prot: sp|Q56WD9|THIK2_ARATH 3-ketoacyl-CoA thiolase 2, peroxisomal; TrEMBL-Plants: tr|A0A151S7N8|A0A151S7N8_CAJCA 3-ketoacyl-CoA thiolase 2, peroxisomal; Found in the gene: LotjaGi6g1v0014400 | 18 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT2G33150.1 peroxisomal 3-ketoacyl-CoA thiolase 3; Swiss-Prot: sp|Q56WD9|THIK2_ARATH 3-ketoacyl-CoA thiolase 2, peroxisomal; TrEMBL-Plants: tr|A0A151S7N8|A0A151S7N8_CAJCA 3-ketoacyl-CoA thiolase 2, peroxisomal; Found in the gene: LotjaGi6g1v0014400 | 19 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT2G33150.1 peroxisomal 3-ketoacyl-CoA thiolase 3; Swiss-Prot: sp|Q56WD9|THIK2_ARATH 3-ketoacyl-CoA thiolase 2, peroxisomal; TrEMBL-Plants: tr|A0A151S7N8|A0A151S7N8_CAJCA 3-ketoacyl-CoA thiolase 2, peroxisomal; Found in the gene: LotjaGi6g1v0014400 | 17 | ||
| – | 3-ketoacyl-CoA thiolase; TAIR: AT5G47720.1 Thiolase family protein; Swiss-Prot: sp|Q9FIK7|THIC2_ARATH Probable acetyl-CoA acetyltransferase, cytosolic 2; TrEMBL-Plants: tr|M5WS77|M5WS77_PRUPE Uncharacterized protein; Found in the gene: LotjaGi6g1v0024400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00751 | CDD | 1 | 6.67 |