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IPR020830 is a Glyceraldehyde 3-phosphate dehydrogenase, active site.
<p>Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis and gluconeogenesis [[cite:PUB00003246]] by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate. The enzyme exists as a tetramer of identical subunits, each containing 2 conserved functional domains: an NAD-binding domain, and a highly conserved catalytic domain [[cite:PUB00000277]]. The enzyme has been found to bind to actin and tropomyosin, and may thus have a role in cytoskeleton assembly. Alternatively, the cytoskeleton may provide a framework for precise positioning of the glycolytic enzymes, thus permitting efficient passage of metabolites from enzyme to enzyme [[cite:PUB00000277]].</p> <p>GAPDH displays diverse non-glycolytic functions as well, its role depending upon its subcellular location. For instance, the translocation of GAPDH to the nucleus acts as a signalling mechanism for programmed cell death, or apoptosis [[cite:PUB00014242]]. The accumulation of GAPDH within the nucleus is involved in the induction of apoptosis, where GAPDH functions in the activation of transcription. The presence of GAPDH is associated with the synthesis of pro-apoptotic proteins like BAX, c-JUN and GAPDH itself.</p> <p>GAPDH has been implicated in certain neurological diseases: GAPDH is able to bind to the gene products from neurodegenerative disorders such as Huntington's disease, Alzheimer's disease, Parkinson's disease and Machado-Joseph disease through stretches encoded by their CAG repeats. Abnormal neuronal apoptosis is associated with these diseases. Propargylamines such as deprenyl increase neuronal survival by interfering with apoptosis signalling pathways via their binding to GAPDH, which decreases the synthesis of pro-apoptotic proteins [[cite:PUB00014241]].</p> <p>A cysteine in the middle of the molecule is involved in forming a covalent phosphoglycerol thioester intermediate. The sequence around this cysteine is totally conserved in eubacterial and eukaryotic GAPDHs and is also present, albeit in a variant form, in the otherwise highly divergent archaebacterial GAPDH [[cite:PUB00001370]]. The pattern in this entry represents the active site.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. | ||
Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: glyceraldehyde-3-phosphate dehydrogenase, cytosolic-like [Cicer arietinum] gi|502135422|ref|XP_004502328.1| | 19 | ||
– | PREDICTED: glyceraldehyde-3-phosphate dehydrogenase B, chloroplastic-like [Cicer arietinum] gi|502131017|ref|XP_004500847.1| | 19 | ||
– | PREDICTED: glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic-like [Glycine max] gi|356561064|ref|XP_003548805.1| | 19 | ||
– | PREDICTED: glyceraldehyde-3-phosphate dehydrogenase, cytosolic-like [Glycine max] gi|356558930|ref|XP_003547755.1| | 23 | ||
– | PREDICTED: glyceraldehyde-3-phosphate dehydrogenase, cytosolic-like [Cicer arietinum] gi|502176240|ref|XP_004515830.1| | 19 | ||
– | PREDICTED: glyceraldehyde-3-phosphate dehydrogenase, cytosolic-like [Glycine max] gi|356511540|ref|XP_003524483.1| | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G42970.1 glyceraldehyde-3-phosphate dehydrogenase B subunit; Swiss-Prot: sp|P12859|G3PB_PEA Glyceraldehyde-3-phosphate dehydrogenase B, chloroplastic; TrEMBL-Plants: tr|I1K7A9|I1K7A9_SOYBN Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi1g1v0567800 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G42970.1 glyceraldehyde-3-phosphate dehydrogenase B subunit; Swiss-Prot: sp|P25857|G3PB_ARATH Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic; TrEMBL-Plants: tr|W8SQT6|W8SQT6_9ROSA Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi1g1v0567800 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G42970.1 glyceraldehyde-3-phosphate dehydrogenase B subunit; Swiss-Prot: sp|P25857|G3PB_ARATH Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic; TrEMBL-Plants: tr|W8SQT6|W8SQT6_9ROSA Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi1g1v0567800 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G12900.5 glyceraldehyde 3-phosphate dehydrogenase A subunit 2; Swiss-Prot: sp|P12858|G3PA_PEA Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic; TrEMBL-Plants: tr|I1ML66|I1ML66_SOYBN Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi1g1v0637100 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G12900.5 glyceraldehyde 3-phosphate dehydrogenase A subunit 2; Swiss-Prot: sp|P12858|G3PA_PEA Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic; TrEMBL-Plants: tr|B9RGT1|B9RGT1_RICCO Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi1g1v0637100 | 24 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G12900.5 glyceraldehyde 3-phosphate dehydrogenase A subunit 2; Swiss-Prot: sp|P12858|G3PA_PEA Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic; TrEMBL-Plants: tr|F8UX79|F8UX79_ARAHY Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi1g1v0637100 | 24 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|Q7FAH2|G3PC2_ORYSJ Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic; TrEMBL-Plants: tr|I1K135|I1K135_SOYBN Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi2g1v0082700 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT3G04120.1 glyceraldehyde-3-phosphate dehydrogenase C subunit 1; Swiss-Prot: sp|Q7FAH2|G3PC2_ORYSJ Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic; TrEMBL-Plants: tr|V7C2N5|V7C2N5_PHAVU Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi2g1v0082700 | 16 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G79530.1 glyceraldehyde-3-phosphate dehydrogenase of plastid 1; Swiss-Prot: sp|Q9SAJ6|G3PP1_ARATH Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic; TrEMBL-Plants: tr|I1MM44|I1MM44_SOYBN Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi3g1v0133700 | 23 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G79530.1 glyceraldehyde-3-phosphate dehydrogenase of plastid 1; Swiss-Prot: sp|Q9SAJ6|G3PP1_ARATH Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic; TrEMBL-Plants: tr|I1MM44|I1MM44_SOYBN Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi3g1v0133700 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G16300.1 glyceraldehyde-3-phosphate dehydrogenase of plastid 2; Swiss-Prot: sp|Q9SAJ6|G3PP1_ARATH Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic; TrEMBL-Plants: tr|I1MM44|I1MM44_SOYBN Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi3g1v0133700 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|P34922|G3PC_PEA Glyceraldehyde-3-phosphate dehydrogenase, cytosolic; TrEMBL-Plants: tr|I3SYQ7|I3SYQ7_LOTJA Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi4g1v0223800 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|P34922|G3PC_PEA Glyceraldehyde-3-phosphate dehydrogenase, cytosolic; TrEMBL-Plants: tr|I3SYQ7|I3SYQ7_LOTJA Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi4g1v0223800 | 18 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|P34922|G3PC_PEA Glyceraldehyde-3-phosphate dehydrogenase, cytosolic; TrEMBL-Plants: tr|I3SYQ7|I3SYQ7_LOTJA Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi4g1v0223800 | 18 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|P34922|G3PC_PEA Glyceraldehyde-3-phosphate dehydrogenase, cytosolic; TrEMBL-Plants: tr|I3SYQ7|I3SYQ7_LOTJA Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi4g1v0223800 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|Q7FAH2|G3PC2_ORYSJ Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic; TrEMBL-Plants: tr|V7D036|V7D036_PHAVU Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi6g1v0100900 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|Q7FAH2|G3PC2_ORYSJ Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic; TrEMBL-Plants: tr|V7D036|V7D036_PHAVU Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi6g1v0100900 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|Q7FAH2|G3PC2_ORYSJ Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic; TrEMBL-Plants: tr|V7D036|V7D036_PHAVU Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi6g1v0100900 | 19 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|Q7FAH2|G3PC2_ORYSJ Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic; TrEMBL-Plants: tr|V7D036|V7D036_PHAVU Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi6g1v0100900 | 20 | ||
– | Glyceraldehyde-3-phosphate dehydrogenase; TAIR: AT1G13440.1 glyceraldehyde-3-phosphate dehydrogenase C2; Swiss-Prot: sp|Q7FAH2|G3PC2_ORYSJ Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic; TrEMBL-Plants: tr|V7D036|V7D036_PHAVU Glyceraldehyde-3-phosphate dehydrogenase; Found in the gene: LotjaGi6g1v0100900 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
TIGR01534 | TIGRFAM | 1 | 3.85 |