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IPR020855 is a Ureohydrolase, manganese-binding site.
<p>The ureohydrolase superfamily includes arginase ([ec:3.5.3.1]), agmatinase ([ec:3.5.3.11]), formiminoglutamase ([ec:3.5.3.8]) and proclavaminate amidinohydrolase ([ec:3.5.3.22]) [[cite:PUB00028086]]. These enzymes share a 3-layer α-β-α structure [[cite:PUB00028086], [cite:PUB00028087], [cite:PUB00025337]], and play important roles in arginine/agmatine metabolism, the urea cycle, histidine degradation, and other pathways.</p> <p>Arginase, which catalyses the conversion of arginine to urea and ornithine, is one of the five members of the urea cycle enzymes that convert ammonia to urea as the principal product of nitrogen excretion [[cite:PUB00001437]]. There are several arginase isozymes that differ in catalytic, molecular and immunological properties. Deficiency in the liver isozyme leads to argininemia, which is usually associated with hyperammonemia.</p> <p>Agmatinase hydrolyses agmatine to putrescine, the precursor for the biosynthesis of higher polyamines, spermidine and spermine. In addition, agmatine may play an important regulatory role in mammals.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. | ||
| Molecular function | Metal ion binding | Interacting selectively and non-covalently with any metal ion. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: arginase-like [Cicer arietinum] gi|502146607|ref|XP_004506527.1| | 12 | ||
| – | PREDICTED: arginase-like [Cicer arietinum] gi|502146607|ref|XP_004506527.1| | 12 | ||
| – | PREDICTED: arginase-like [Cicer arietinum] gi|502146607|ref|XP_004506527.1| | 12 | ||
| – | Arginase; TAIR: AT4G08900.1 arginase; Swiss-Prot: sp|P46637|ARGI1_ARATH Arginase 1, mitochondrial; TrEMBL-Plants: tr|I3SK83|I3SK83_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0435700 | 12 | ||
| – | Arginase; TAIR: AT4G08900.1 arginase; Swiss-Prot: sp|P46637|ARGI1_ARATH Arginase 1, mitochondrial; TrEMBL-Plants: tr|I3SK83|I3SK83_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0435700 | 12 | ||
| – | Arginase family protein; TAIR: AT4G08900.1 arginase; Swiss-Prot: sp|P46637|ARGI1_ARATH Arginase 1, mitochondrial; TrEMBL-Plants: tr|G7JFU5|G7JFU5_MEDTR Arginase family protein; Found in the gene: LotjaGi3g1v0435800 | 12 | ||
| – | Arginase; TAIR: AT4G08870.1 Arginase/deacetylase superfamily protein; Swiss-Prot: sp|O49046|ARGI_SOYBN Arginase; TrEMBL-Plants: tr|A0A0B2RR74|A0A0B2RR74_GLYSO Arginase; Found in the gene: LotjaGi3g1v0435900 | 13 | ||
| – | Arginase; TAIR: AT4G08870.1 Arginase/deacetylase superfamily protein; Swiss-Prot: sp|O49046|ARGI_SOYBN Arginase; TrEMBL-Plants: tr|I3SM21|I3SM21_MEDTR Uncharacterized protein; Found in the gene: LotjaGi3g1v0436000 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11593 | CDD | 1 | 12.50 |