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IPR021715 is a Pre-mRNA-splicing factor SLU7 domain.
<p>The spliceosome, an assembly of snRNAs (U1, U2, U4/U6, and U5) and proteins, catalyses the excision of introns from pre-mRNAs in two successive trans-esterification reactions [[cite:PUB00090374]]. Step 2 depends upon integral spliceosome constituents such as U5 snRNA and Prp8 and non-spliceosomal proteins Prp16, Slu7, Prp18, and Prp22. ATP hydrolysis by the DEAH-box enzyme Prp16 promotes a conformational change in the spliceosome that leads to protection of the 3' splice site from targeted RNase H cleavage. This change, which probably reflects binding of the 3' splice site PyAG in the catalytic centre of the spliceosome, requires the ordered recruitment of Slu7, Prp18, and Prp22 to the spliceosome. There is a close functional relationship between Prp8, Prp18, and Slu7, and Prp18 interacts with Slu7, so that together they recruit Prp22 to the spliceosome. Most members of the family carry a zinc-finger of the CCHC-type upstream of this domain; this retains the protein within the nucleus [[cite:PUB00090375]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pre-mRNA-splicing factor SLU7-A-like [Glycine max] gi|356567955|ref|XP_003552180.1| | 6 | ||
| – | PREDICTED: pre-mRNA-splicing factor SLU7-like [Cucumis sativus] gi|449482878|ref|XP_004156430.1| | 6 | ||
| – | Pre-mRNA-splicing factor SLU7-like protein; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|A0A072UDN9|A0A072UDN9_MEDTR Pre-mRNA-splicing factor SLU7-like protein; Found in the gene: LotjaGi1g1v0210600 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7-like protein; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|I1N2J3|I1N2J3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0210600 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7-like protein; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|A2YQU8|SLU7_ORYSI Pre-mRNA-splicing factor SLU7; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|A2YQU8|SLU7_ORYSI Pre-mRNA-splicing factor SLU7; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 | ||
| – | Pre-mRNA-splicing factor SLU7; TAIR: AT1G65660.1 Pre-mRNA splicing Prp18-interacting factor; Swiss-Prot: sp|Q9SHY8|SLU7A_ARATH Pre-mRNA-splicing factor SLU7-A; TrEMBL-Plants: tr|A0A0A0LFN9|A0A0A0LFN9_CUCSA Uncharacterized protein; Found in the gene: LotjaGi5g1v0190800 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |